Results 171 to 180 of about 9,151 (264)

A Proteolytic Process to Simulate the Mechanics of Disc Dengeration in Bovine Cadaveric Tissue

, 2011
Purpose. The present work hypothesized that proteolytic dissolution of intervertebral discs could induce biomechanical change comparable to the change observed in natural disc degeneration.
Bishop, Timothy A.
core  

Stress-driven design of intervertebral disc implants and optimization of mechanical and biological performance. [PDF]

J Orthop Translat
Zhang M, Pang S, Wang Y, Xue Y, Wu X, Chen W, Qin YX.   +6 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Strain distribution on metastatic spine segments before and after intervertebral disc degeneration

Intervertebral disc degeneration causes anatomical and mechanical changes to the spine, leading to increased flexibility and consequent instability.
Di Flumeri, Giorgia
core  

Calibration of Hyperelastic Material Properties of the Human Lumbar Intervertebral Disc under Fast Dynamic Compressive Loads

, 2011
Under fast dynamic loading conditions (e.g. high-energy impact), the load rate dependency of the intervertebral disc (IVD) material properties may play a crucial role in the biomechanics of spinal trauma.
Garo, Anais, El Rich, Marwan, Wragnac, Eric, Aubin, Carl-Eric, Arnoux, Pierre-Jean   +4 more
core  

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Dehnel's Phenomenon in Mammals

Mammal Review, Volume 56, Issue 2, June 2026.
Some small mammals, which remain active year‐round, undergo reversible reductions in body size, braincase height, and the mass of internal organs, including the brain, from summer to winter. It is called Dehnel's phenomenon. In this review, we summarise knowledge of the mechanisms, adaptive value, and genetic basis of the phenomenon, and show how new ...
Jan R. E. Taylor, Cecilia Baldoni, Dina K. N. Dechmann   +2 more
wiley   +1 more source

Correlation of Clinical and MRI Findings With Intraoperative Findings in Lumbar Intervertebral Disc Prolapse: A Prospective Observational Study. [PDF]

Cureus
R NB, Ethiraj P, Sakalecha AK, Reddy A B.   +3 more
europepmc   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

O‐Arm Navigation Enhances Facet Preservation Without Compromising Clinical Outcomes in UBE Decompression for Radiographically Stable Adult Degenerative Scoliosis: A Single‐Center Comparative Study

Orthopaedic Surgery, Volume 18, Issue 6, Page 1203-1215, June 2026.
O‐arm navigation–assisted unilateral biportal endoscopic decompression achieves precise and sufficient neural decompression in stable adult degenerative scoliosis, enhancing facet preservation and reducing segmental motion changes while maintaining comparable symptomatic improvement to conventional fluoroscopy, demonstrating the value of navigation in ...
Yi Liu, Yiwei Xie, Zhibao Chen, Ruijun Xu, Haojie Chen, Xiaojian Ye, Jiangming Yu   +6 more
wiley   +1 more source