Results 71 to 80 of about 45,413 (272)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Long-term creep behavior of the intervertebral disk: comparison between bioreactor data and numerical results [PDF]

, 2014
The loaded disk culture system is an intervertebral disk (IVD)-oriented bioreactor developed by the VU Medical Center (VUmc, Amsterdam, The Netherlands), which has the capacity of maintaining up to 12 IVDs in culture, for approximately 3 weeks after ...
Alves, J. L., Castro, André, Claro, José Carlos Pimenta, Detiger, S. E. L., Mullender, M. G., Paul, C. P. L., Royen, B. J. van, Smit, T. H.   +7 more
core   +2 more sources

Multi-Scale Context-Guided Lumbar Spine Disease Identification with Coarse-to-fine Localization and Classification [PDF]

arXiv, 2022
Accurate and efficient lumbar spine disease identification is crucial for clinical diagnosis. However, existing deep learning models with millions of parameters often fail to learn with only hundreds or dozens of medical images. These models also ignore the contextual relationship between adjacent objects, such as between vertebras and intervertebral ...
arxiv  

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

Advanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang   +9 more
wiley   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

Examination of an in-vitro methodology to evaluate the biomechanical performance of nucleus augmentation in axial compression [PDF]

, 2017
Intervertebral disc degeneration is one of the leading causes of back pain, but treatment options remain limited. Recently, there have been advances in the development of biomaterials for nucleus augmentation; however, the testing of such materials ...
Mengoni, M, Miles, DE, Sikora, SNF, Tarsuslugil, S, Wilcox, RK   +4 more
core   +2 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Friction in metal-on-metal total disc arthroplasty: effect of ball radius [PDF]

, 2012
Total Disc Arthroplasty (TDA) can be used to replace a degenerated intervertebral disc in the spine. There are different designs of prosthetic discs, but one of the most common is a ball-and-socket combination.
Hukins, DWL, Mahomed, A, Moghadas, PM, Shepherd, DET   +3 more
core   +1 more source

Context-Aware Transformers For Spinal Cancer Detection and Radiological Grading [PDF]

arXiv, 2022
This paper proposes a novel transformer-based model architecture for medical imaging problems involving analysis of vertebrae. It considers two applications of such models in MR images: (a) detection of spinal metastases and the related conditions of vertebral fractures and metastatic cord compression, (b) radiological grading of common degenerative ...
arxiv  

Impact of through‐slice gradient optimization for dynamic slice‐wise shimming in the cervico‐thoracic spinal cord

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose This study investigates the effectiveness of through‐slice gradient optimization in dynamic slice‐wise B0 shimming of the cervico‐thoracic spinal cord to enhance signal recovery in gradient‐echo (GRE) EPI sequences commonly used in functional MRI studies. Methods Six volunteers underwent MRI acquisitions with dynamic shim updating (DSU)
Arnaud Breheret, Alexandre D'Astous, Yixin Ma, Jason P. Stockmann, Julien Cohen‐Adad   +4 more
wiley   +1 more source