Results 71 to 80 of about 13,470 (264)

Sensitivity analysis of permeability parameters of bovine nucleus pulposus obtained through inverse fitting of the nonlinear biphasic equation : effect of sampling strategy [PDF]

, 2012
Permeability controls the fluid flow into and out of soft tissue, and plays an important role in maintaining the health status of such tissue. Accurate determination of the parameters that define permeability is important for the interpretation of models
Biot MA, Guo L-X, Lai WM, Lide DR, Malandrino A, Mansour JM, Philip E. Riches   +6 more
core   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Brachioradial pruritus in a patient with cervical disc herniation and Parsonage-Turner syndrome [PDF]

Anais Brasileiros de Dermatologia, 2015
Brachioradial pruritus is a chronic sensory neuropathy of unknown etiology which affects the skin of the shoulders, arms and forearms on the insertion of the brachioradialis muscle.
Sandrina Carvalho, Madalena Sanches, Rosário Alves, Manuela Selores   +3 more
doaj   +1 more source

Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc - Reduced risk of osteophyte formation. [PDF]

, 2014
Mesenchymal stem cells (MSCs) have the potential to treat early intervertebral disc (IVD) degeneration. However, during intradiscal injection, the vast majority of cells leaked out even in the presence of hydrogel carrier.
An, XM, Chan, BP, Cheung, KMC, Chik, TK, Chow, ST, Diao, HJ, Leung, VYL, Li, YY   +7 more
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Mechanical influence of facet tropism in patients with chronic discogenic pain disorder

Bone & Joint Research
Aims: The presence of facet tropism has been correlated with an elevated susceptibility to lumbar disc pathology. Our objective was to evaluate the impact of facet tropism on chronic lumbosacral discogenic pain through the analysis of clinical data and ...
Jun Y. Lee, Hae I. Lee, Sang-Heon Lee, Nack H. Kim   +3 more
doaj   +1 more source

Biomechanical assessment of the effects of decompressive surgery in non-chondrodystrophic and chondrodystrophic canine multisegmented lumbar spines [PDF]

, 2012
Purpose Dogs are often used as an animal model in spinal research, but consideration should be given to the breed used as chondrodystrophic (CD) dog breeds always develop IVD degeneration at an early age, whereas nonchondrodystrophic (NCD) dog breeds may
Bergknut, Niklas, Dhert, Wouter J. A., Hazewinkel, Herman A. W., Kingma, Idsart, Meij, Björn P., Smolders, Lucas A., van der Veen, Albert J., van Dieën, Jaap H.   +7 more
core   +5 more sources

Anti‐Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration

Advanced Science, EarlyView.
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen, Hao Han, Yuhao Zhang, Longyu Li, Zhishuo Wang, Jiaming Zhang, Liang Han, Hongwei Kou, Guowei Shang, Chunfeng Shang, Zikuan Leng, Keya Mao, Chengwei Li, Lin Jin, Hongjian Liu   +14 more
wiley   +1 more source

A structurally and functionally biomimetic biphasic scaffold for intervertebral disc tissue engineering. [PDF]

, 2015
Tissue engineering offers high hopes for the treatment of intervertebral disc (IVD) degeneration. Whereas scaffolds of the disc nucleus and annulus have been extensively studied, a truly biomimetic and mechanically functional biphasic scaffold using ...
Chan, BP, Choy, THA
core   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source