Results 121 to 130 of about 22,569 (256)

A new target for treating intervertebral disk degeneration: gut microbes. [PDF]

open access: yesFront Microbiol
Wang K   +8 more
europepmc   +1 more source

Larger Lumbar Vertebral Body Osteophyte Volume Is Associated With Older Age and a More Caudal Vertebral Level in Individuals With Chronic Low Back Pain

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Procrustes analysis was used to match osteophyte‐free lumbar vertebral bodies to lumbar vertebral bodies containing osteophytes. The volume of the reference library bone was subtracted to create an osteophyte model, from which regional osteophyte volumes were calculated.
Clarissa LeVasseur   +8 more
wiley   +1 more source

Intradiscal Cutibacterium acnes Sustains Modic Type 1‐Like Lesions Over Time in a Rat Lumbar Endplate Injury Model

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Intradiscal C. acnes injection sustained MC1‐like lesions with persistent neutrophil sustenance in an etiology‐specific lumbar MC rat model. This suggests that patients with bacterial MC etiology may persist in painful MC1, highlighting C. acnes and neutrophils as potential targets to promote MC1‐to‐MC2 conversion and improve pain and disability ...
Irina Heggli   +12 more
wiley   +1 more source

Detrimental Effect of Low‐Magnitude High‐Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Low‐magnitude high‐frequency vibration (LMHFV), with or without 17β‐oestradiol (E2), exacerbated papain‐induced bovine intervertebral disc degeneration, reducing cell viability, impairing matrix production, and increasing inflammation. E2 showed no protective effect against papain‐induced degeneration or LMHFV.
Jan Ulrich Jansen   +9 more
wiley   +1 more source

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