Results 71 to 80 of about 2,378,273 (384)

Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport ManganeseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: SLC11A2 (DMT1) and SLC40A1 (ferroportin) are essential for dietary iron absorption, but their role in manganese transport is debated.
Milankumar Prajapati, Jared Z. Zhang, Grace S. Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga Antipova, Barry Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas B. Bartnikas   +13 more
doaj   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation

Pharmaceutics, 2021
The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within
Arik Dahan, Isabel González-Álvarez
doaj   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

eLife
The intestinal absorption of essential nutrients, especially those not readily biosynthesized, is a critical physiological process for maintaining homeostasis.
Yoshihisa Mimura, Tomoya Yasujima, Katsuhisa Inoue, Shogo Akino, Chitaka Namba, Hiroyuki Kusuhara, Yutaro Sekiguchi, Kinya Ohta, Takahiro Yamashiro, Hiroaki Yuasa   +9 more
doaj   +1 more source

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

Stem Cell Reports, 2018
Summary: The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs.
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi   +6 more
doaj   +1 more source

Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption

Pharmaceutics, 2021
The small intestine provides the major site for the absorption of numerous orally administered drugs. However, before reaching to the systemic circulation to exert beneficial pharmacological activities, the oral drug delivery is hindered by poor ...
Nutthapoom Pathomthongtaweechai, Chatchai Muanprasat   +1 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +1 more source

Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets [PDF]

, 2020
The monoterpene thymol has been proposed as a valuable alternative to in-feed antibiotics in animal production. However, the effectiveness of the antimicrobial is comprised by its fast absorption in the upper gastrointestinal tract.
De Smet, Stefaan, Degroote, Jeroen, Desmet, Tom, Michiels, Joris, Van Liefferinge, Elout, Van Noten, Noémie   +5 more
core   +1 more source