Results 51 to 60 of about 352,113 (307)

Repairing the intestinal mucosal barrier of traditional Chinese medicine for ulcerative colitis: a review

Frontiers in Pharmacology, 2023
Damage to the intestinal mucosal barrier play an important role in the pathogenesis of ulcerative colitis (UC). Discovering the key regulators and repairing the disturbed barrier are crucial for preventing and treating UC.
Yichen Zong, Jie Meng, Tangyou Mao, Qiang Han, Peng Zhang, Lei Shi   +5 more
doaj   +1 more source

Intestinal barrier in inflammatory bowel disease

World Journal of Gastroenterology, 2014
A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we provide an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides (AMPs) and the ...
Lena, Antoni, Sabine, Nuding, Jan, Wehkamp, Eduard F, Stange   +3 more
openaire   +3 more sources

Intestinal Mucin Glycosylation: Structural Regulation, Homeostasis Maintenance and Disease Association

Biomolecules
The intestinal barrier is a complex configuration that defends against external assaults and maintains intestinal health. Disruption of barrier function can lead to intestinal inflammation and various diseases.
Yunye Li, Jia Pan, Huimin Liu, Chuanguo Liu   +3 more
doaj   +1 more source

Effects of Docetaxel Injection and Docetaxel Micelles on the Intestinal Barrier and Intestinal Microbiota

Advanced Science, 2021
Increasing evidence has suggested that chemotherapeutics affect the integrity of the intestinal barrier and alter the intestinal microbiota, thus limiting the therapeutic outcomes of cancer chemotherapy.
Qingya Liu, Yi Lu, Yao Xiao, Liping Yuan, Danrong Hu, Ying Hao, Ruxia Han, Jinrong Peng, Zhiyong Qian   +8 more
doaj   +1 more source

TLR/MyD88-Mediated Inflammation Induced in Porcine Intestinal Epithelial Cells by Ochratoxin A Affects Intestinal Barrier Function

Toxics, 2023
The intestinal epithelium performs vital functions such as nutrient absorption and acting as an intestinal barrier to maintain the host’s homeostasis. Mycotoxin, which affects the processing and storage of animal feedstuff, is a problematic pollutant in ...
Jung Woong Yoon, Sangsu Shin, JeongWoong Park, Bo Ram Lee, Sang In Lee   +4 more
doaj   +1 more source

The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors [PDF]

, 2015
OBJECTIVE: Gut barrier is a functional unit organized as a multi-layer system and its multiple functions are crucial for maintaining gut homeostasis. Numerous scientific evidences showed a significant association between gut barrier leaking and gastro ...
Bruno, G, Franceschi, F, Gasbarrini, A, Lopetuso, Lr, Petito, V, Scaldaferri, F   +5 more
core  

Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish [PDF]

, 2016
Indexación: Web of ScienceIntestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with ...
Alaurent, Trevor G. S., Caruffo, Mario, Dantagnan, Patricio, De la Paz, Javiera F., Feijóo, Carmen G., Hernández, Adrián J., Solís, Camila J., Ulloa, Pilar E.   +7 more
core   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis

Journal of Inflammation, 2022
Background Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD).
Jiping Zhao, Hong Wang, Jintao zhang, Fuwei Ou, Junfei Wang, Tian Liu, Jinxiang Wu   +6 more
doaj   +1 more source

Intestine‐Specific Expression of Human Chimeric Intestinal Alkaline Phosphatase Attenuates Western Diet‐Induced Barrier Dysfunction and Glucose Intolerance [PDF]

, 2018
Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen.
Ghosh, Shobha, Ghosh, Siddhartha S., He, Hongliang, Korzun, William, Wang, Jing, Yannie, Paul J.   +5 more
core   +1 more source