Adenosine in Intestinal Epithelial Barrier Function [PDF]
CellsAt the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier.
Mariya Stepanova, Carol M. Aherne
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Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
Ali Shawki, Declan F. McCole
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Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps [PDF]
Frontiers in ImmunologyBackgroundUnder hyperglycemic conditions, impaired intestinal barrier integrity leads to heightened level of inflammation, playing important roles in driving diabetic complications.
Yiqing Cai +14 more
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Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding [PDF]
Frontiers in Immunology, 2017 Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Angela M. Patterson +3 more
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Journal of Immunology Research, 2022 Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms.
Yuejin Li +7 more
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Microbiome, 2023 Background The intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins. Growing studies have linked the gut microbiota to the intestinal epithelial barrier function.
Jun Hu +5 more
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Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]
, 2015 Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola +10 more
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Human organoids are superior to cell culture models for intestinal barrier research
Frontiers in Cell and Developmental Biology, 2023 Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research.
Catherine Kollmann +10 more
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TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. [PDF]
PLoS ONE, 2011 Tight junctions between intestinal epithelial cells mediate the permeability of the intestinal barrier, and loss of intestinal barrier function mediated by TNF signaling is associated with the inflammatory pathophysiology observed in Crohn's disease and ...
Lauren E Kolodziej +11 more
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Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. [PDF]
PLoS ONE, 2017 The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space.
Hui Yan, Kolapo M Ajuwon
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