Results 261 to 270 of about 196,559 (297)

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

The Use of Polysaccharide AOP30 from the Rhizome of Alpinia officinarum Hance to Alleviate Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction and Inflammation via the TLR4/NfκB Signaling Pathway in Caco-2 Cell Monolayers. [PDF]

Nutrients
Jia X, Huang Y, Liu G, Li Z, Tan Q, Zhong S.   +5 more
europepmc   +1 more source

Saturated fatty acids differently affect mitochondrial function and the intestinal epithelial barrier depending on their chain length in the in vitro model of IPEC-J2 enterocytes. [PDF]

Front Cell Dev Biol
Guerbette T, Rioux V, Bostoën M, Ciesielski V, Coppens-Exandier H, Buraud M, Lan A, Boudry G.   +7 more
europepmc   +1 more source

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C.

J Cell Sci
Segui-Perez C, Stapels DAC, Ma Z, Su J, Passchier E, Westendorp B, Wubbolts RW, Wu W, van Putten JPM, Strijbis K.   +9 more
europepmc   +1 more source

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How autophagy controls the intestinal epithelial barrier

Autophagy, 2021
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of the intestinal epithelium is of particular interest, as several autophagy-related genes have been associated with intestinal ...
Elisabeth G, Foerster, Tapas, Mukherjee, Liliane, Cabral-Fernandes, Juliana D B, Rocha, Stephen E, Girardin, Dana J, Philpott   +5 more
openaire   +2 more sources

Epithelial Barriers in Intestinal Inflammation

Antioxidants & Redox Signaling, 2011
The gastrointestinal epithelium transports solutes and water between lumen and blood and at the same time forms a barrier between these compartments. This highly selective and regulated barrier permits ions, water, and nutrients to be absorbed, but normally restricts the passage of harmful molecules, bacteria, viruses and other pathogens.
Lena J, John, Michael, Fromm, Jörg-Dieter, Schulzke   +2 more
openaire   +2 more sources

Intestinal epithelial barrier functions in ageing

Ageing Research Reviews, 2019
The intestinal epithelial barrier protects the mucosa of the gastrointestinal (GI)-tract and plays a key role in maintaining the host homeostasis. It encompasses several elements that include the intestinal epithelium and biochemical and immunological products, such as the mucus layer, antimicrobial peptides (AMPs) and secretory immunologlobulin A ...
Jacopo J V, Branca, Massimo, Gulisano, Claudio, Nicoletti   +2 more
openaire   +2 more sources

Probiotic bacteria and intestinal epithelial barrier function

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010
The intestinal tract is a diverse microenvironment where more than 500 species of bacteria thrive. A single layer of epithelium is all that separates these commensal microorganisms and pathogens from the underlying immune cells, and thus epithelial barrier function is a key component in the arsenal of defense mechanisms required to prevent infection ...
Christina L, Ohland, Wallace K, Macnaughton   +1 more
openaire   +2 more sources

Regulation of the intestinal epithelial paracellular barrier

Pharmaceutical Science & Technology Today, 1999
Paracellular transport of orally-administered drugs, the passage of molecules between adjacent intestinal epithelial cells, is impeded by a range of structural and functional features found in the intestine. An increased knowledge of the mechanisms that govern the paracellular barrier will enable the pharmaceutical scientist to design novel and ...
, Daugherty, , Mrsny
openaire   +2 more sources

The intestinal epithelial barrier: a therapeutic target? [PDF]

Nature Reviews Gastroenterology and Hepatology, 2016
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions between luminal contents such as the intestinal microbiota, the underlying immune system and the remainder of the body, while supporting vectorial transport of nutrients, water and waste products.
Matthew A Odenwald, Jerrold R Turner
exaly   +3 more sources