Results 31 to 40 of about 196,559 (297)
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]
, 2019 Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica +6 more
core +1 more source
PLK1 protects against sepsis-induced intestinal barrier dysfunction
Scientific Reports, 2018 Sepsis and sepsis-associated intestinal barrier dysfunction are common in intensive care units, with high mortality. The aim of this study is to investigate whether Polo-like kinase 1 (PLK1) ameliorates sepsis-induced intestinal barrier dysfunction in ...
Yingya Cao +7 more
doaj +1 more source
BMC Medicine, 2023 Background Disrupted intestinal epithelial barrier is one of the major causes of Crohn’s disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD.
Longyuan Zhou +7 more
doaj +1 more source
Stem Cell Research, 2019 The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the digestive tract, including inflammatory bowel diseases and colorectal cancer.
Marco Bardenbacher +11 more
doaj +1 more source
Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity [PDF]
Journal of Allergy, 2012 Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance. Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell ...
openaire +2 more sources
Scientific Reports, 2023 The intestinal epithelial barrier, among other compartments such as the mucosal immune system, contributes to the maintenance of intestinal homeostasis.
Elsie Quansah +10 more
doaj +1 more source
Nuts \u27n\u27 guts: transport of food allergens across the intestinal epithelium [PDF]
, 2013 The increase in the incidence of food allergy is a growing problem for the western world. This review will focus on the findings from several macromolecular epithelial transport experiments and drug permeability studies to provide a recent comprehension ...
Ackland,L, Price,Dwan, Suphioglu,C
core +1 more source
IL-1β and the Intestinal Epithelial Tight Junction Barrier [PDF]
Frontiers in Immunology, 2021 The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. A defective intestinal TJ barrier has been implicated as an important pathogenic factor in inflammatory diseases of the gut including Crohn’s disease, ulcerative colitis ...
Lauren W. Kaminsky +2 more
openaire +3 more sources
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]
, 2016 Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson +27 more
core +1 more source
Age-Associated Remodeling of the Intestinal Epithelial Barrier [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013 Disorders of the gastrointestinal tract are common in the elderly people; however, the precise trait(s) of aging that contribute to the vulnerability of the gastrointestinal tract are poorly understood. Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability.
Lee, Tran +1 more
openaire +2 more sources