Results 51 to 60 of about 196,268 (297)

Intestinal epithelial barrier: The target for pathogenic Escherichia coli [PDF]

Advances in Clinical and Experimental Medicine, 2017
Diarrheagenic Escherichia coli strains are included in 9 pathotypes (pathovars) that present different virulence factors responsible for the patomechanism of infections they cause. As all other intestinal pathogens, E. coli exerts a significant effect on intestinal epithelium.
Barbara, Pawłowska, Beata M, Sobieszczańska   +1 more
openaire   +2 more sources

A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins

Cells, 2022
In healthy individuals, tight junction proteins (TJPs) maintain the integrity of the intestinal barrier. Dysbiosis and increased intestinal permeability are observed in several diseases, such as inflammatory bowel disease. Many studies highlight the role
Raffaella di Vito, Carmela Conte, Giovanna Traina   +2 more
doaj   +1 more source

A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. [PDF]

, 2019
Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent
Biagi, M, Borgonetti, V, Carnevali, I, Catanzaro, D, Cocetta, V, Giron, MC, Governa, P, Montopoli, M, Ragazzi, E   +8 more
core   +1 more source

Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function

BMC Veterinary Research, 2020
Background The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases.
Jingtao Wu, Caimei He, Jie Bu, Yue Luo, Shuyuan Yang, Chengyan Ye, Silei Yu, Binsheng He, Yulong Yin, Xiaoping Yang   +9 more
doaj   +1 more source

Bifidobacteria Prevent Tunicamycin-Induced Endoplasmic Reticulum Stress and Subsequent Barrier Disruption in Human Intestinal Epithelial Caco-2 Monolayers. [PDF]

PLoS ONE, 2016
Endoplasmic reticulum (ER) stress is caused by accumulation of unfolded and misfolded proteins in the ER, thereby compromising its vital cellular functions in protein production and secretion.
Takuya Akiyama, Kenji Oishi, Andy Wullaert   +2 more
doaj   +1 more source

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]

, 2019
Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R., Awad, W. A., Hess, C., Hess, M., Khayal, B.   +4 more
core   +1 more source

A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function. [PDF]

, 2019
Intestinal epithelial cell (IEC) junctions constitute a robust barrier to invasion by viruses, bacteria and exposure to ingested agents. Previous studies showed that microgravity compromises the human immune system and increases enteropathogen virulence.
Alvarez, Rocio, Marchelletta, Ronald R, McCole, Declan F, Prisk, G Kim, Sayoc-Becerra, Anica, Stork, Cheryl A   +5 more
core   +1 more source

Inflammatory cytokines directly disrupt the bovine intestinal epithelial barrier

Scientific Reports, 2022
AbstractThe small intestinal mucosa constitutes a physical barrier separating the gut lumen from sterile internal tissues. Junctional complexes between cells regulate transport across the barrier, preventing water loss and the entry of noxious molecules or pathogens.
Crawford, Charles K, Lopez Cervantes, Veronica, Quilici, Mary L, Armién, Aníbal G, Questa, María, Matloob, Muhammad S, Huynh, Leon D, Beltran, Aeelin, Karchemskiy, Sophie J, Crakes, Katti R, Kol, Amir   +10 more
openaire   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source