Results 61 to 70 of about 201,161 (293)

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]

, 2020
IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear, Adrienne W. Paton, Amin-Wetzel, Bertolotti, Bertolotti, Calfon, Chang, Delphine De Sutter, Eva Cloots, Feldman, Haber, Heidi De Luca, Hetz, Hollien, Hollien, Imagawa, Iwawaki, Iwawaki, James C. Paton, Jay R. Thiagarajah, Karagöz, Lee, Li, Lisbona, Lu, Mariska S. Simpson, Markus A. Seeliger, Martino, Mi, Michael J. Grey, Miyoshi, Nicole LeDuc, Paton, Paton, Phi Luong, Prischi, Sepulveda, Shemorry, Singh, Sophie Janssens, Sundaram, Sven Eyckerman, Tam, Tirasophon, Tirasophon, Tschurtschenthaler, Tsuru, Tsuru, Walter, Wang, Wang, Wayne I. Lencer, Wiseman, Yevgeniy V. Serebrenik, Yoshida   +54 more
core   +1 more source

Intestinal Epithelial Barrier Dysfunction in Crohn's Disease

Experimental Biology and Medicine, 1997
Despite extensive research, the etiology of Crohn's disease remains unknown. Accumulating evidence suggests the possibility that a primary defect of intestinal barrier function may be present in Crohn's disease. In this review, the possible role of intestinal barrier defect in Crohn's disease is discussed.
openaire   +2 more sources

Microenvironmental modulation of the intestinal epithelial barrier [PDF]

, 2022
A healthy gut is essential for human health and healthy aging. Indeed, many diseases are characterized by a disturbed function of the gut, which is often reflected by an abnormal composition of the gut microbiota, e.g., the gut bacteria that help in food digestion and immune regulation.
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis

Canadian Journal of Gastroenterology and Hepatology, 2019
Objective. Recently, blueberry has been identified as a candidate for the treatment of liver fibrosis. Given the role of gut-liver axis in liver fibrosis and the importance of the gut microbiota homeostasis to the maintenance of the intestinal epithelial
Zhiqiang Yan, Fang Yang, Zhu Hong, Shishun Wang, Zhang Jinjuan, Bing Han, Rujia Xie, Feiyun Leng, Qin Yang   +8 more
doaj   +1 more source

A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression

BMC Complementary Medicine and Therapies, 2022
Background Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory ...
Sasi Kumar Murugan, Bharathi Bethapudi, Subramanian Raghunandhakumar, Divya Purusothaman, Muruganantham Nithyanantham, Deepak Mundkinajeddu, Muralidhar Srinivasaih Talkad   +6 more
doaj   +1 more source

Lactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathway

Frontiers in Microbiology, 2022
Intestinal mucositis promoted by the use of anticancer drugs is characterized by ulcerative inflammation of the intestinal mucosa, a debilitating side effect in cancer patients undergoing treatment.
Fernanda Alvarenga Lima Barroso, Luís Cláudio Lima de Jesus, Tales Fernando da Silva, Viviane Lima Batista, Juliana Laguna, Nina Dias Coelho-Rocha, Kátia Duarte Vital, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Enio Ferreira, Flaviano Santos Martins, Mariana Martins Drumond, Mariana Martins Drumond, Pamela Mancha-Agresti, Alexander Birbrair, Debmalya Barh, Debmalya Barh, Vasco Azevedo   +17 more
doaj   +1 more source

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]

, 2019
Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R., Awad, W. A., Hess, C., Hess, M., Khayal, B.   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mechanisms underlying bone loss associated with gut inflammation [PDF]

, 2019
Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation.
Abu-Amer, Yousef, Arra, Manoj, Ke, Ke
core   +2 more sources