Results 241 to 250 of about 434,779 (308)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction. [PDF]

Gut Microbes
Jacobs SO, Muenchau S, Uckeley ZM, Passarelli GV, David A, Briggs S, Burke JM, Stanifer ML, Boulant S.   +8 more
europepmc   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Dysregulated programmed cell death of intestinal epithelial cells in ulcerative colitis: Molecular mechanisms and novel therapeutic interventions (Review). [PDF]

Int J Mol Med
Wu B, Su S, Li Y, Guo L.
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Retraction: Effect of berberine on LPS-induced expression of NF-κB/MAPK signalling pathway and related inflammatory cytokines in porcine intestinal epithelial cells. [PDF]

Innate Immun
europepmc   +1 more source

Zinc inhibits cAMP-induced Cl^- secretion in intestinal epithelial cells via calcium-sensing receptor. [PDF]

Am J Physiol Cell Physiol
Yottasan P, Chu T, Gao Q, Chhetri P, Tas ST, Cil O.   +5 more
europepmc   +1 more source

Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells. [PDF]

J Transl Med
Zhou Q, Liu L, Lin X, Shen B, Huang W, Zhang Y, Li Y, Yang Y, Liu H, Zhang W, Zhao X, Qiao W, Liu Y, Tan G, Zhi F.   +14 more
europepmc   +1 more source

Murine intestinal epithelial cells and lymphocytes undergo contrasting inflammatory shifts during gastrointestinal development. [PDF]

Pediatr Res
Wiemers TC, Riedel J, Dressler N, Feng X, Peukert N, Lacher M, Mayer S.   +6 more
europepmc   +1 more source