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Epithelial Stem Cells and Intestinal Cancer

Seminars in Cancer Biology, 2015
The mammalian intestine is comprised of an epithelial layer that serves multiple functions in order to maintain digestive activity as well as intestinal homeostasis. This epithelial layer contains highly proliferative stem cells which facilitate its characteristic rapid regeneration.
Nick Barker
exaly   +3 more sources

EPITHELIAL CELL MIGRATION IN THE INTESTINE

Cell Biology International, 1996
AbstractDespite significant advances in our understanding of the roles of the cytoskeleton and matrix receptors in cell locomotion, derived largely fromin vitrostudies on the movement of epithelial cell sheets and isolated cells, the mechanism of epithelial cell migration in the adult intestine remains an enigma.
openaire   +2 more sources

The intestinal epithelial cell: immunological aspects

Springer Seminars in Immunopathology, 1997
IECs likely play an important role in immunological defense mechanism. Apart from being a passive barrier against luminal bacteria, IECs secrete protective and microbiocidal products such as ITF, complement components and cryptdins into the lumen. Moreover, IECs produce secretory component that is essential for the transport of IgA from the lamina ...
A D, Christ, R S, Blumberg
openaire   +2 more sources

Antigen presentation by intestinal epithelial cells

Immunology Today, 1993
This is the first book dealing with the subject of antigen presentation by intestinal epithelial cells. It brings together experimental evidence and discussion which shed some light on the pathophysiological relevance of epithelial cells in intestinal immune defence mechanisms.
D, Kaiserlian, K, Vidal
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Cell Volume Regulation in Intestinal Epithelial Cells

2004
A plethora of signaling cascades is activated upon hyposmotic stimulation of mammalian cells. In Intestine 407 cells, p21Rho as well as tyrosine kinase(s) and PtdIns-3- kinase were found to be a prerequisite for VRAC activation, whereas protein kinase C is likely to be involved in the regulation of a distinct organic osmolyte release pathway.
Sebastian, Tomassen   +2 more
openaire   +2 more sources

Stability of Protein in Intestinal Epithelial Cells

Science, 1961
In vivo measurements have revealed a high degree of stability of synthesized protein in rapidly proliferating intestinal epithelial cells. A slow loss of protein has been found during migration of mature cells to the villus tip.
Lipkin, M, Almy, T P, Quastler, H
openaire   +2 more sources

Neutrophil-Epithelial Cell Interactions in the Intestine

1991
PMN transmigration across intestinal epithelia and into crypt lumens is a hallmark of active intestinal disease. Models of the transmigratory event indicate that movement of PMN across intercellular tight junctions transiently increases junctional permeability, thus decreasing epithelial barrier function.
J L, Madara, S, Nash, C, Parkos
openaire   +2 more sources

Intestinal Epithelial Stem Cells and Progenitors

2006
The adult intestinal epithelium contains a relatively simple, highly organized, and readily accessible stem cell system. Excellent methods exist for the isolation of intestinal epithelium from adults, and as a result collecting large quantities of intestinal stem and progenitor cells for study or culture and subsequent clinical applications should be ...
Matthew, Bjerknes, Hazel, Cheng
openaire   +2 more sources

Conditionally Immortalized Intestinal Epithelial Cells: A New Model for Studying Intestinal Epithelial Cell Turnover

Annals of the New York Academy of Sciences, 1998
Conditionally immortalized intestinal epithelial cells - A new model for studying intestinal epithelial cell ...
V, Milovic, G, Ocklind, P, Artursson
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Cytology of Intestinal Epithelial Cells

1968
Publisher Summary This chapter focuses on the cytology of intestinal epithelial cells. Three major technical advances have determined the methodology of recent investigations of intestinal epithelial cytology. In the first place, the advent of simple and reliable intestinal biopsy techniques has made possible the detailed study of the human intestine
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