Results 61 to 70 of about 437,417 (289)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PLK1 protects against sepsis-induced intestinal barrier dysfunction

Scientific Reports, 2018
Sepsis and sepsis-associated intestinal barrier dysfunction are common in intensive care units, with high mortality. The aim of this study is to investigate whether Polo-like kinase 1 (PLK1) ameliorates sepsis-induced intestinal barrier dysfunction in ...
Yingya Cao, Qun Chen, Zhen Wang, Tao Yu, Jingyi Wu, Xiaogan Jiang, Xiaoju Jin, Weihua Lu   +7 more
doaj   +1 more source

Intestinal Transport: Studies with Isolated Epithelial Cells [PDF]

Environmental Health Perspectives, 1979
Isolated intestinal epithelial cells have been extremely useful for characterizing the nature of intestinal absorption processes and for providing insight into the energetics of Na(+)-dependent transport systems. This report describes a number of experimental approaches which have been used for investigating the specific epithelial transport systems ...
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

Stem Cell Reports, 2018
Summary: The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs.
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi   +6 more
doaj   +1 more source

Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate

Scientific Reports, 2022
Intestinal epithelial cells and the intestinal microbiota are in a mutualistic relationship that is dependent on communication. This communication is multifaceted, but one aspect is communication through compounds produced by the microbiota such as the ...
Menno Grouls, Aafke W. F. Janssen, Loes P. M. Duivenvoorde, Guido J. E. J. Hooiveld, Hans Bouwmeester, Meike van der Zande   +5 more
doaj   +1 more source

Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome. [PDF]

, 2012
Background/aimsCampylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We
Alpern, Joel, Barlow, Gillian M, Chang, Christopher, Hwang, Laura, Jee, Sam-Ryong, Khoshini, Reza, Low, Kimberly, Marsh, Zachary, Morales, Walter, Pimentel, Mark, Pokkunuri, Venkata, Wang, Hanlin, Weitsman, Stacy   +12 more
core   +1 more source

"Tolerosomes" are produced by intestinal epithelial cells [PDF]

European Journal of Immunology, 2001
The development of immunological tolerance to orally fed antigens depends on the sampling, processing and transportation events followed in the intestinal epithelium. We present here a description of a "tolerosome": a supra-molecular, exosome-like structure assembled in and released from the small intestinal epithelial cell.
M, Karlsson, S, Lundin, U, Dahlgren, H, Kahu, I, Pettersson, E, Telemo   +5 more
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia

Bioelectronic Medicine, 2020
Background Recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagates in intestinal epithelial cells expressing Angiotensin-Converting Enzyme 2 (ACE2), implying that these cells represent an important entry ...
Anne S. ten Hove, David J. Brinkman, Andrew Y. F. Li Yim, Caroline Verseijden, Theo B. M. Hakvoort, Iris Admiraal, Olaf Welting, Patricia H. P. van Hamersveld, Valérie Sinniger, Bruno Bonaz, Misha D. Luyer, Wouter J. de Jonge   +11 more
doaj   +1 more source