Results 41 to 50 of about 5,424,793 (311)

Genome sequence of Lactobacillus amylovorus GRL1112 [PDF]

, 2011
Lactobacillus amylovorus is a common member of the normal gastrointestinal tract (GIT) microbiota in pigs. Here, we report the genome sequence of L. amylovorus GRL1112, a porcine feces isolate displaying strong adherence to the pig intestinal epithelial ...
Vos, W.M., de, Lars Paulin, Edward Alatalo, Willem M. de Vos, Paulin, L., Ravi Kant, Palva, A., Kant, R., Airi Palva, Alatalo, E.   +9 more
core   +1 more source

Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Stem Cell Research & Therapy
Background Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-dimensional structure of organoids
JunLong Chen, Shinichiro Horiuchi, So Kuramochi, Tomoyuki Kawasaki, Hayato Kawasumi, Saeko Akiyama, Tomoki Arai, Kenichi Morinaga, Tohru Kimura, Tohru Kiyono, Hidenori Akutsu, Seiichi Ishida, Akihiro Umezawa   +12 more
doaj   +1 more source

Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the GutSummary

Cellular and Molecular Gastroenterology and Hepatology
The intestinal epithelium forms the boundary between the intestinal immune system in the lamina propria and the outside world, the intestinal lumen, which contains a diverse array of microbial and environmental antigens.
Eva Liebing, Susanne M. Krug, Markus F. Neurath, Britta Siegmund, Christoph Becker   +4 more
doaj   +1 more source

Impact of Epithelial Cell Shedding on Intestinal Homeostasis

International Journal of Molecular Sciences, 2022
The gut barrier acts as a first line of defense in the body, and plays a vital role in nutrition and immunoregulation. A layer of epithelial cells bound together via intercellular junction proteins maintains intestinal barrier integrity. Based on a tight equilibrium between cell extrusion and cell restitution, the renewal of the epithelium (epithelial ...
Ngo, Phuong A., Neurath, Markus F., López-Posadas, Rocío   +2 more
openaire   +2 more sources

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases

Journal of Immunology Research, 2019
Intestinal epithelial cells cover the surface of the intestinal tract. The cells are important for preserving the integrity of the mucosal barriers to protect the host from luminal antigens and pathogens.
Wakana Ohashi, Toshiyuki Fukada
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-catenin and focal adhesion kinase signaling pathways

Scientific Reports
The regeneration of epithelia is crucial for maintaining intestinal homeostasis. Irisin is an exercise-induced hormone originally found to be secreted by skeletal muscles, thereby regulating energy metabolism.
Arong Gaowa, Supasuta Leangpanich, Eun Jeong Park, Eiji Kawamoto, Motomu Shimaoka   +4 more
doaj   +1 more source

Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats

Stem Cell Research & Therapy, 2021
Background Sepsis is a major cause of death in ICU, and intestinal barrier dysfunction is its important complication, while the treatment is limited. Recently, mesenchymal stem cell-derived microvesicles (MMVs) attract much attention as a strategy of ...
Danyang Zheng, Henan Zhou, Hongchen Wang, Yu Zhu, Yue Wu, Qinghui Li, Tao Li, Liangming Liu   +7 more
doaj   +1 more source