Results 21 to 30 of about 434,779 (308)

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

Epigenetics in Intestinal Epithelial Cell Renewal [PDF]

Journal of Cellular Physiology, 2016
A controlled balance between cell proliferation and differentiation is essential to maintain normal intestinal tissue renewal and physiology. Such regulation is powered by several intracellular pathways that are translated into the establishment of specific transcription programs, which influence intestinal cell fate along the crypt-villus axis.
Roostaee, Alireza, Benoit, Yannick D., Boudjadi, Salah, Beaulieu, Jean‐François   +3 more
openaire   +2 more sources

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin [PDF]

, 2012
Background: The gastrointestinal tract is the first target for the potentially harmful effects of mycotoxins after intake of mycotoxin contaminated food or feed.
Croubels, Siska, De Backer, Patrick, De Baere, Siegrid, Goossens, Joline, Haesebrouck, Freddy, Meyer, Evelyne, Pasmans, Frank, Vandenbroucke, Virginie, Verbrugghe, Elin   +8 more
core   +2 more sources

Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells. [PDF]

, 2019
In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to external stimuli.
Ding, Eom, Fawaz G Haj, Folin, Guiguo Zhang, Heo, Hyo-Seon Yang, Inhae Kang, Myoungsook Lee, Shirosaki, Shon, Wells, Wolfrom, Yunkyoung Lee   +13 more
core   +1 more source

Binding Studies on Isolated Porcine Small Intestinal Mucosa and in vitro Toxicity Studies Reveal Lack of Effect of C. perfringens Beta-Toxin on the Porcine Intestinal Epithelium

Toxins, 2015
Beta-toxin (CPB) is the essential virulence factor of C. perfringens type C causing necrotizing enteritis (NE) in different hosts. Using a pig infection model, we showed that CPB targets small intestinal endothelial cells.
Simone Roos, Marianne Wyder, Ahmet Candi, Nadine Regenscheit, Christina Nathues, Filip van Immerseel, Horst Posthaus   +6 more
doaj   +1 more source

Peroxisomes in intestinal and gallbladder epithelial cells of the stickleback, Gasterosteus aculeatus L. (Teleostei) [PDF]

, 1988
The occurrence of microbodies in the epithelial cells of the intestine and gallbladder of the stickleback, Gasterosteus aculeatus L., is described. In the intestine the organelles are predominantly located in the apical and perinuclear zone of the cells ...
AJH Ruiter de, AJH Ruiter de, BF Trump, CH Lowry, DH Fickeisen, F Roels, F Roels, G Duve De, GM Small, H Goldenberg, H Goldenberg, H Honma, H Kindl, H L�ck, JM Lord, M Veenhuis, M Veenhuis, M Veenhuis, MJ Connock, MJ Connock, P B�ck, R Kramar, TL Gritzka, Z Hruban   +23 more
core   +4 more sources

Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors.
Chunling Ma, Xiaoming Yang, Qiulan Lv, Zhimei Yan, Zeqing Chen, Daxing Xu, Xiu Liu, Wan Yang, Shichao Xing   +8 more
doaj   +1 more source

Rotavirus Interactions With Host Intestinal Epithelial Cells [PDF]

Frontiers in Immunology, 2021
Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in young children (<5years) and animals worldwide. RV primarily infects mature enterocytes in the intestinal epithelium causing villus atrophy, enhanced epithelial cell turnover and apoptosis.
Joshua Oluoch Amimo, Joshua Oluoch Amimo, Sergei Alekseevich Raev, Juliet Chepngeno, Alfred Omwando Mainga, Alfred Omwando Mainga, Yusheng Guo, Linda Saif, Anastasia N. Vlasova   +8 more
openaire   +3 more sources

Innate lymphoid cells regulate intestinal epithelial cell glycosylation [PDF]

Science, 2014
Immune cells and bugs make a sugary coat Epithelial cells line the intestinal tract and help to keep the peace between our immune system and our trillions of gut microbes. Such peacekeeping requires glycosylated proteins (proteins with attached carbohydrate chains) present on the epithelial cell surface, but how glycosylation ...
Goto, Yoshiyuki, Obata, Takashi, Kunisawa, Jun, Sato, Shintaro, Ivanov, Ivaylo I, Lamichhane, Aayam, Takeyama, Natsumi, Kamioka, Mariko, Sakamoto, Mitsuo, Matsuki, Takahiro, Setoyama, Hiromi, Imaoka, Akemi, Uematsu, Satoshi, Akira, Shizuo, Domino, Steven E, Kulig, Paulina, Becher, Burkhard, Renauld, Jean-Christophe, Sasakawa, Chihiro, Umesaki, Yoshinori, Benno, Yoshimi, Kiyono, Hiroshi   +21 more
openaire   +3 more sources