Results 31 to 40 of about 5,424,793 (311)

Intestinal epithelial cells in health and disease. [PDF]

Tissue Barriers
This comprehensive review delves into the pivotal role of intestinal epithelial cells in the context of various diseases. It provides an in-depth analysis of the diverse types and functions of these cells, explores the influence of multiple signaling pathways on their differentiation, and elucidates their critical roles in a spectrum of diseases.
An C, Jiang C, Pei W, Li A, Wang M, Wang Y, Wang H, Zuo L.   +7 more
europepmc   +3 more sources

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.

PLoS Genetics, 2016
Zinc transporters play a critical role in spatiotemporal regulation of zinc homeostasis. Although disruption of zinc homeostasis has been implicated in disorders such as intestinal inflammation and aberrant epithelial morphology, it is largely unknown ...
Wakana Ohashi, Shunsuke Kimura, Toshihiko Iwanaga, Yukihiro Furusawa, Tarou Irié, Hironori Izumi, Takashi Watanabe, Atsushi Hijikata, Takafumi Hara, Osamu Ohara, Haruhiko Koseki, Toshiro Sato, Sylvie Robine, Hisashi Mori, Yuichi Hattori, Hiroshi Watarai, Kenji Mishima, Hiroshi Ohno, Koji Hase, Toshiyuki Fukada   +19 more
doaj   +1 more source

Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors.
Chunling Ma, Xiaoming Yang, Qiulan Lv, Zhimei Yan, Zeqing Chen, Daxing Xu, Xiu Liu, Wan Yang, Shichao Xing   +8 more
doaj   +1 more source

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation [PDF]

Frontiers in Immunology, 2017
Pattern recognition receptors (PRR), such as NOD-like receptors (NLRs), sense conserved microbial signatures, and host danger signals leading to the coordination of appropriate immune responses. Upon activation, a subset of NLR initiate the assembly of a multimeric protein complex known as the inflammasome, which processes pro-inflammatory cytokines ...
Lei-Leston, Andrea, Murphy, Alison G., Maloy, Kevin J.   +2 more
openaire   +4 more sources

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction [PDF]

, 2008
Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene.
Ussar, S, Moritz Widmaier, Fässler, R., Genzel-Boroviczeny, O., Fässler, R, Rognoni, E, Moser, M., Markus Moser, Christian Harrer, Harrer, C., Emanuel Rognoni, Moser, Markus, Reinhard Fässler, Genzel-Boroviczeny, Orsolya, Siegfried Ussar, Ussar, Siegfried, Genzel-Boroviczeny, O, Faessler, Reinhard, Widmaier, M, Harrer, C, Rognoni, E., Harrer, Christian, Widmaier, M., Orsolya Genzel-Boroviczeny, Moser, M, Ussar, S., Widmaier, Moritz, Rognoni, Emanuel   +27 more
core   +2 more sources

Clostridium butyricum Ameliorates Salmonella Enteritis Induced Inflammation by Enhancing and Improving Immunity of the Intestinal Epithelial Barrier at the Intestinal Mucosal Level

Frontiers in Microbiology, 2020
This study was aimed to investigate the effects of Clostridium butyricum (C. butyricum) immunity and intestinal epithelial barrier function at the intestinal mucosal level, by using Salmonella enteritidis (S. enteritidis) to infect specific-pathogen-free
Xiaonan Zhao, Xiaonan Zhao, Jie Yang, Zijing Ju, Jianmin Wu, Lili Wang, Hai Lin, Shuhong Sun   +7 more
doaj   +1 more source

Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans [PDF]

, 2009
Background: Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E.
Short, Abigail J., Abigail J Short, Maddocks, Oliver D. K., Donnenberg, Michael S., Abigail J. Short, David J Harrison, Oliver D K Maddocks, Bader, Scott, Scott Bader, Michael S. Donnenberg, Michael S Donnenberg, Maddocks, Oliver D.K., Oliver D. K. Maddocks, David J. Harrison, Harrison, David J., Harrison, David J.; id_orcid   +15 more
core   +2 more sources

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Cell Reports, 2019
Summary: Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced
José Luís Fachi, Jaqueline de Souza Felipe, Laís Passariello Pral, Bruna Karadi da Silva, Renan Oliveira Corrêa, Mirella Cristiny Pereira de Andrade, Denise Morais da Fonseca, Paulo José Basso, Niels Olsen Saraiva Câmara, Éricka Lorenna de Sales e Souza, Flaviano dos Santos Martins, Suzana Eiko Sato Guima, Andrew Maltez Thomas, João Carlos Setubal, Yuli Thamires Magalhães, Fábio Luis Forti, Thamiris Candreva, Hosana Gomes Rodrigues, Marcelo Bispo de Jesus, Sílvio Roberto Consonni, Alessandro dos Santos Farias, Patrick Varga-Weisz, Marco Aurélio Ramirez Vinolo   +22 more
doaj   +1 more source

Vesicular traffic in polarized epithelial cells : identification and characterization of general and epithelial specific factors [PDF]

, 1994
Polarized epithelial cells are differentiated into apical and basolateral plasma membrane domains separated by tight junctions. The apical cell surface usually faces the external milieu, the basolateral domain provides cell-cell and cell-substratum ...
Fiedler, Klaus
core   +1 more source

Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions [PDF]

BMC Genomics, 2009
AbstractBackgroundEmerging evidences suggest that enteric glial cells (EGC), a major constituent of the enteric nervous system (ENS), are key regulators of intestinal epithelial barrier (IEB) functions. Indeed EGC inhibit intestinal epithelial cells (IEC) proliferation and increase IEB paracellular permeability.
van Landeghem, Laurianne, Mahé, Maxime, Teusan, Raluca, Léger, Jean, Guisle, Isabelle, Houlgatte, Rémi, Neunlist, Michel   +6 more
openaire   +4 more sources