Results 61 to 70 of about 434,779 (308)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

Intestinal Transport: Studies with Isolated Epithelial Cells [PDF]

Environmental Health Perspectives, 1979
Isolated intestinal epithelial cells have been extremely useful for characterizing the nature of intestinal absorption processes and for providing insight into the energetics of Na(+)-dependent transport systems. This report describes a number of experimental approaches which have been used for investigating the specific epithelial transport systems ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science
Hepatic progenitor cells (HPCs) are frequently overactivated, and their differentiation into hepatocytes is impaired in advanced liver diseases. To explore the effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of ...
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
doaj   +1 more source

PLK1 protects against sepsis-induced intestinal barrier dysfunction

Scientific Reports, 2018
Sepsis and sepsis-associated intestinal barrier dysfunction are common in intensive care units, with high mortality. The aim of this study is to investigate whether Polo-like kinase 1 (PLK1) ameliorates sepsis-induced intestinal barrier dysfunction in ...
Yingya Cao, Qun Chen, Zhen Wang, Tao Yu, Jingyi Wu, Xiaogan Jiang, Xiaoju Jin, Weihua Lu   +7 more
doaj   +1 more source

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

Stem Cell Reports, 2018
Summary: The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs.
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi   +6 more
doaj   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

"Tolerosomes" are produced by intestinal epithelial cells [PDF]

European Journal of Immunology, 2001
The development of immunological tolerance to orally fed antigens depends on the sampling, processing and transportation events followed in the intestinal epithelium. We present here a description of a "tolerosome": a supra-molecular, exosome-like structure assembled in and released from the small intestinal epithelial cell.
M, Karlsson, S, Lundin, U, Dahlgren, H, Kahu, I, Pettersson, E, Telemo   +5 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source