Results 61 to 70 of about 5,424,793 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science
Hepatic progenitor cells (HPCs) are frequently overactivated, and their differentiation into hepatocytes is impaired in advanced liver diseases. To explore the effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of ...
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
doaj   +1 more source

Isolation and 3-dimensional Culture of Primary Murine Intestinal Epithelial Cells

Bio-Protocol, 2014
The intestine, together with skin and blood, belongs to the organs with the highest cell turnover, which makes it a perfect model to study cellular processes, such as proliferation and differentiation.
Agnieszka Pastula, Michael Quante
doaj   +1 more source

Characterization of the spatio-temporal dynamics in thymic epithelial development [PDF]

, 2015
The work presented in this thesis is centered on the development and maturation of the epithelial compartment in the murine thymus and consequently its functional capacity to promote normal thymopoiesis. Two main aspects have been investigated in depth:
Mayer, Carlos E.
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

Stem Cell Reports, 2018
Summary: The small intestine plays an important role in the absorption and metabolism of oral drugs. In the current evaluation system, it is difficult to predict the precise absorption and metabolism of oral drugs.
Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi   +6 more
doaj   +1 more source

Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells. [PDF]

, 2012
C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C.
Tilo Biedermann (116048), Jeanette Wagener (116035), Weig, Michael S., Susanne Kaesler (116042), Jeanette Wagener, Bader, Oliver, Schaller, Martin, Albert D. de Boer (116041), Naglik, Julian R., Naglik, Julian R, Piet W. J. de Groot (116040), Daniela Mailänder-Sanchez (116045), Weindl, Günther, Julian R Naglik, Hans Christian Korting (116050), Günther Weindl, Martin Schaller, Julian R. Naglik (116049), Selvam Thavaraj (116043), Albert D de Boer, Oliver Bader, Hans Christian Korting, de Boer, Albert D, Albert D. De Boer, Oliver Bader (116044), Claudia Borelli (116046), Selvam Thavaraj, Borelli, Claudia, Daniela Mailänder-Sanchez, Susanne Kaesler, Günther Weindl (116038), Biedermann, Tilo, Michael Weig, Michael Weig (116047), Claudia Borelli, de Boer, Albert D., Weindl, Guenther, Mailaender-Sanchez, Daniela, Julian R. Naglik, Kaesler, Susanne, de Groot, Piet W. J., Thavaraj, Selvam, Korting, Hans Christian, Mailänder-Sanchez, Daniela, Apoptosis Of Epithelial Cells, Piet W. J. De Groot, Martin Schaller (116051), Wagener, Jeanette, Weig, Michael, Tilo Biedermann, Piet W J de Groot, Naglik, Julian R; id_orcid, de Groot, Piet W J, Bader Oliver, Biedermann Tilo, Naglik Julian R., Weig Michael, Korting Hans Christian, Schaller Martin, de Groot Piet W. J., Kaesler Susanne, Mailänder-Sanchez Daniela, Borelli Claudia, Mailänder-Sánchez, Daniela Isabel, Thavaraj Selvam, Weindl Günther, Wagener Jeanette, de Boer Albert D.   +67 more
core   +1 more source

Acute cytomegalovirus infection modulates the intestinal microbiota and targets intestinal epithelial cells [PDF]

, 2023
Primary and recurrent cytomegalovirus (CMV) infections frequently cause CMV colitis in immunocompromised as well as inflammatory bowel disease (IBD) patients.
Baier, Franziska, Ebel, Jana‐Fabienne, Krebs, Philippe, Lange, Christian M., Christian M. Lange, Westendorf, Astrid M., Wohlgemuth, Kerstin, Alexandra Adamczyk, Astrid M. Westendorf, Determann, Madita, Jana‐Fabienne Ebel, Madita Determann, Katschinski, Benjamin, Benjamin Katschinski, Robert Klopfleisch, Viktoriya Sokolova, Franziska Baier, Aart Mookhoek, Trilling, Mirko, Pfeifer, Kai Robin, Kerstin Wohlgemuth, Mookhoek, Aart, Vu Thuy Khanh Le‐Trilling, Kai Robin Pfeifer, Adamczyk, Alexandra, Sokolova, Viktoriya, Lange, Erik, Erik Lange, Le‐Trilling, Vu Thuy Khanh, Philippe Krebs, Mirko Trilling, Klopfleisch, Robert   +31 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Development of two alternative models of campylobacter jejuni infection that more closely mimic the in vivo environment [PDF]

Campylobacter JeJum IS the leading cause of foodborne gastroenteritis worldwide, yet despite the organism's prevalence, relatively little is known about the mechanisms of pathogenesis.
Mills, Dominic Christopher
core   +1 more source