Results 81 to 90 of about 5,424,793 (311)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Enhanced Utilization of Induced Pluripotent Stem Cell–Derived Human Intestinal Organoids Using Microengineered ChipsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background and Aims: Human intestinal organoids derived from induced pluripotent stem cells have tremendous potential to elucidate the intestinal epithelium’s role in health and disease, but it is difficult to directly assay these complex structures ...
Michael J. Workman, John P. Gleeson, Elissa J. Troisi, Hannah Q. Estrada, S. Jordan Kerns, Christopher D. Hinojosa, Geraldine A. Hamilton, Stephan R. Targan, Clive N. Svendsen, Robert J. Barrett   +9 more
doaj   +1 more source

The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia

Bioelectronic Medicine, 2020
Background Recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagates in intestinal epithelial cells expressing Angiotensin-Converting Enzyme 2 (ACE2), implying that these cells represent an important entry ...
Anne S. ten Hove, David J. Brinkman, Andrew Y. F. Li Yim, Caroline Verseijden, Theo B. M. Hakvoort, Iris Admiraal, Olaf Welting, Patricia H. P. van Hamersveld, Valérie Sinniger, Bruno Bonaz, Misha D. Luyer, Wouter J. de Jonge   +11 more
doaj   +1 more source

Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]

PLoS ONE, 2014
Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon, Joannie M Allaire, Christine Jones, François Boudreau, Nathalie Perreault   +4 more
doaj   +1 more source

Early transcriptional response in the jejunum of germ-free piglets after oral infection with virulent rotavirus [PDF]

, 2008
Germ-free piglets were orally infected with virulent rotavirus to collect jejunal mucosal scrapings at 12 and 18 hours post infection (two piglets per time point).
Hulst, M.M., Wit, A.A.C., de, Niewold, T., Meulen, J., van der, Smits, M.A., Kerstens, H.H.D.   +5 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis

Cell Death and Disease
Intestinal epithelial renewal, which depends on the proliferation and differentiation of intestinal stem cells (ISCs), is essential for epithelial homoeostasis. Understanding the mechanism controlling ISC activity is important.
Jianbo Liu, Kaixuan Liu, Ying Wang, Ziru Shi, Runze Xu, Yundi Zhang, Jingxin Li, Chuanyong Liu, Bing Xue   +8 more
doaj   +1 more source

Advances in intestinal epithelium and gut microbiota interaction

Frontiers in Microbiology
The intestinal epithelium represents a critical interface between the host and external environment, serving as the second largest surface area in the human body after the lungs.
Sen Yang, Sen Yang, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu   +9 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source