Results 91 to 100 of about 5,424,793 (311)

Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

Frontiers in Pharmacology, 2018
Background and Aim: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal and pelvic cancer or occurs secondary to accidental radiation exposure.
Hyosun Jang, Janet Lee, Sunhoo Park, Sunhoo Park, Hyunwook Myung, Jihoon Kang, Kyuchang Kim, Hyewon Kim, Won-Suk Jang, Sun-Joo Lee, Sehwan Shim, Jae K. Myung, Jae K. Myung   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Bettina Kempf, Partilla, Miriam, Jens Waschke, Hartlieb, Eva, Waschke, Jens, Kempf, Bettina, Eva Hartlieb (103934), Vigh, Balázs, Miriam Partilla, Miriam Partilla (103942), Balázs Vigh, Bettina Kempf (103938), Eva Hartlieb, Volker Spindler (103952), Balázs Vigh (103947), Jens Waschke (103956), Spindler, Volker, Volker Spindler, Partilla Miriam, Spindler Volker, Waschke Jens, Kempf Bettina, Vigh Balázs, Hartlieb Eva   +23 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Characterization of cells of amniotic fluids by immunological identification of intermediate-sized filaments: Presence of cells of different tissue origin [PDF]

, 1981
Antibodies against intermediate-sized filaments, of the prekeratin or vimentin type, were used to investigate the presence of these filaments by indirect immunofluorescence microscopy in cultured and non-cultured amniotic fluid cells, in frozen sections ...
Cremer, Thomas, Treiss, I., Cremer, Marion, Franke, W. W., Hager, D.   +4 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Zebrafish

Cell Reports
Summary: Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and driving tissue regeneration. The zebrafish intestine features a distinctive furrow-ruga architecture and lacks the crypt structures characteristic of mammalian
Guozhen Wu, Xiangyong Wei, Liqi Zhang, Bangzhuo Huang, Jialong Fu, Jieqiong Zhao, Yanbo Huang, Xinmiao Tan, Xue Ma, Xiaoqian Fu, Jianbo He, Rui Ni, Qifen Yang, Lingfei Luo, Yun Yang   +14 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Isolation, establishment, and characterization of immortalized ileum bovine intestinal epithelial cell line

Scientific Reports
Primary intestinal epithelial cells are a powerful tool to study tight junction protein function and barrier integrity of epithelial cells. However, primary cells are costly, difficult to isolate, have a finite ability to replicate, and require the usage
Hannah K. Piper, Mitchell J. Wiese, Mitchell J. Poss   +2 more
doaj   +1 more source

LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defense

Frontiers in Immunology
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic defensive responses against intracellular pathogens, including intracellular parasites. Interferons(IFNs) have been identified as cornerstones of epithelial
Zinat Sharmin, Kehua Jin, Kehua Jin, Ai-Yu Gong, Silu Deng, Chansorena Pok, Marion L. Graham, Shuhong Wang, Nicholas W. Mathy, Annemarie Shibata, Xian-Ming Chen   +10 more
doaj   +1 more source