Results 101 to 110 of about 5,424,793 (311)

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.), Sadik, Christian David, Bachmann, Malte, Mühl, Heiko   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The intestinal epithelial stem cell: the mucosal governor

International Journal of Experimental Pathology, 1997
All epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To‐date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred.
C S, Potten, C, Booth, D M, Pritchard
openaire   +3 more sources

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay [PDF]

CARD14 is an intracellular NF-κB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC).
Mira Haegman, Steven C Ley, de Oliveira Collaco, Rita de Cassia, Carels, Marieke, Haegman, Mira, Ley, Steven C., Cássia Collaço, Rita de, Bosmans, Frank, van de Wiele, Tom, Afonina, Inna S., Aidarova, Aigerim, Steven Timmermans, Tom Van de Wiele, Beyaert, Rudi, Maria Francesca Viola, Driege, Yasmine, Inna S Afonina, Joan Manils, de Cassia Collaco, Rita, Aigerim Aidarova, Aguilera-Lizarraga, Javier, Manils, Joan, Damme, Eline van, Frank Bosmans, Libert, Claude, Viola, Maria Francesca, Afonina, Inna, Boeckxstaens, Guy, Javier Aguilera-Lizarraga, Van Damme, Eline, Claude Libert, Marieke Carels, Eline Van Damme, Guy Boeckxstaens, Timmermans, Steven, Rudi Beyaert, Yasmine Driege, Rita de Cássia Collaço, Wiele, Tom van de   +38 more
core   +1 more source

Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization [PDF]

, 2010
Contains fulltext : 88219.pdf (Publisher’s version ) (Open Access)BACKGROUND: Probiotics can be used to stimulate or regulate epithelial and immune cells of the intestinal mucosa and generate beneficial mucosal immunomodulatory effects.
Kleerebezem, M., Vos, P., de, Bilsen, J., van Bilsen Jolanda, Meijerink Marjolein, Savelkoul, H.F.J., Bron, P.A., Savelkoul Huub F., Bilsen, J.G.P.M., van, Huub F. Savelkoul, Wells Jerry M., Vos, P., Marjolein Meijerink, Jolanda van Bilsen, Bron, Peter A., Wells, J., Savelkoul, Huub F., de Vos Paul, Huub F Savelkoul, Saskia van Hemert, Michiel Wels, van Hemert Saskia, Meijerink, M., Jerry M Wells, Kleerebeezem, M., van Bilsen, Jolanda, Wels, Michiel, Kleerebezem, Michiel, Paul de Vos, Michiel Kleerebezem, Kleerebezem Michiel, Peter A. Bron, Taverne, Nico, Taverne Nico, Taverne, N., van Hemert, Saskia, de Vos, Paul, Bron Peter A., Peter A Bron, de Vos, Paul; id_orcid, Wells, J.M., Wels Michiel, Nico Taverne, Hemert, S. van, Hemert, S., van, Wells, Jerry M., Jerry M. Wells, Wels, M.W.W., Sanders, M.W.W., Meijerink, Marjolein   +49 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Opinion: Are Organoids the End of Model Evolution for Studying Host Intestinal Epithelium/Microbe Interactions?

Microorganisms, 2019
In the pursuit to understand intestinal epithelial cell biology in health and disease, researchers have established various model systems, from whole animals (typically rodents) with experimentally induced disease to transformed human carcinomas.
Michelle M. George, Mushfiqur Rahman, Jessica Connors, Andrew W. Stadnyk   +3 more
doaj   +1 more source

Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]

, 2006
Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Choquet, A, Balda, MS, Hollande, F, Matter, K, Tsapara, A, Kavanagh, E, Buchert, M   +6 more
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative escherichia coli [PDF]

, 2011
Background: Enteropathogenic (EPEC) and Enteroaggregative (EAEC) E. coli have similar, but distinct clinical symptoms and modes of pathogenesis. Nevertheless when they infect the gastrointestinal tract, it is thought that their flagellin causes IL-8 ...
Nigel J Klein, Simon H Murch, Edwards Lindsey A., Klein, Nigel J, Phillips, Alan D., Edwards, LA, Phillips, AD, Simon H. Murch, Edwards, Lindsey A., Phillips, Alan D, Mona Bajaj-Elliott, Lindsey A Edwards, Alan D. Phillips, Murch, SH, Bajaj-Elliott, Mona, Alan D Phillips, Klein Nigel J., Murch Simon H., Nigel J. Klein, Klein, NJ, Phillips Alan D., Klein, Nigel, Lindsey A. Edwards, Murch, Simon H, Bajaj-Elliott, M, Murch, Simon, Bajaj-Elliott Mona, Edwards, Lindsey A; id_orcid   +27 more
core   +1 more source