Results 101 to 110 of about 434,779 (308)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse [PDF]

, 2013
Bcl-3 is a member of the IκB family of proteins and is an essential negative regulator of Toll-like receptor induced responses. Recently, a single nucleotide polymorphism associated with reduced Bcl-3 gene expression has been identified as a potential ...
Araki, Carmody, Costello, Cummins, Dann, Fransen, Ghosh, Hayden, Karrasch, Kerr, Kreisel, Murphy, Nenci, Neurath, Nolan, O'Connor, Ota, Rakoff-Nahoum, Schreiber, Schwarz, Steinbrecher, Tambuwala, Tao, Vereecke, Wullaert, Zenewicz, Zhang   +26 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Isolation, establishment, and characterization of immortalized ileum bovine intestinal epithelial cell line

Scientific Reports
Primary intestinal epithelial cells are a powerful tool to study tight junction protein function and barrier integrity of epithelial cells. However, primary cells are costly, difficult to isolate, have a finite ability to replicate, and require the usage
Hannah K. Piper, Mitchell J. Wiese, Mitchell J. Poss   +2 more
doaj   +1 more source

LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defense

Frontiers in Immunology
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic defensive responses against intracellular pathogens, including intracellular parasites. Interferons(IFNs) have been identified as cornerstones of epithelial
Zinat Sharmin, Kehua Jin, Kehua Jin, Ai-Yu Gong, Silu Deng, Chansorena Pok, Marion L. Graham, Shuhong Wang, Nicholas W. Mathy, Annemarie Shibata, Xian-Ming Chen   +10 more
doaj   +1 more source

Long-term culture captures injury-repair cycles of colonic stem cells [PDF]

, 2019
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key ...
Chen, Feidi, Cheng, Jiye, Chiang, I-Ling, Fujii, Satoru, Gordon, Jeffrey I, Han, Nathan D, Janova, Hana, Lai, Chin-Wen, Liu, Ta-Chiang, Lu, Qiuhe, Muegge, Brian D, Ohara, Takahiro E, Sibley, L David, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Ver Heul, Aaron, Wang, Yi, Whitehurst, Charles E, Wu, Renee, Xiong, Shanshan   +19 more
core   +1 more source

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]

, 2018
Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R, Escusa, Hazel S, Fletterick, Robert J, Ingraham, Holly A, Klein, Ophir D, Moore, David D, Nattiv, Roy, Suzawa, Miyuki, Wang, Hongtao   +8 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources