Results 161 to 170 of about 669,928 (206)
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Inflammasomes of the intestinal epithelium
Trends in Immunology, 2015While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within ...
Sellin Mikael E. +3 more
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Lineage Tracing in the Intestinal Epithelium
Current Protocols in Stem Cell Biology, 2010AbstractThis unit describes the theory and detailed protocols for performing in vivo lineage tracing from Lgr5+ve intestinal stem cells using an Lgr5‐EGFP‐ires‐CreERT2/Rosa26lacZ mouse model. Lineage tracing can be initiated in mice at any age by administering limiting doses of the hormone tamoxifen. This activates the lacZ reporter gene in the Lgr5+ve
Barker, N., Clevers, H.
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Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium
Current Opinion in Genetics & Development, 2022Vital functions of the intestines: digestion, absorption, and surface barrier are performed by the intestinal epithelium, which consists of various differentiated cells and intestinal stem cells. Recent technological advances in sequencing technology, including single-cell transcriptomics and epigenetic analysis, have facilitated the genetic ...
Mayumi, Oda +2 more
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Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium [PDF]
Journal of Cell Biology, 2007 International audienceThe HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells.
Philippe Blache +2 more
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Glycosphingolipids and the differentiation of intestinal epithelium
Experimental Cell Research, 1981Abstract Changes in lipid-bound cell surface carbohydrates during cell differentiation were studied in epithelial cells of rat small intestine (crypt and villus tip cells). The identity of the cells was established by morphological and enzymatic criteria. Acid and non-acid glycosphingolipids were analysed by thin-layer chromatography, with a separate
M E, Breimer +3 more
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The Ontogeny of the Small Intestinal Epithelium
Journal of Parenteral and Enteral Nutrition, 1999The primary factors in feeding premature infants are dependent on the development and maturation of digestion and absorption. The maturation of digestive and absorptive functions of carbohydrates, proteins, fats, minerals, and vitamins in the young premature infant were determined in relation to availability of hydrolytic enzymes, such as lipases ...
A, Lebenthal, E, Lebenthal
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Transcriptional regulation of metabolism in the intestinal epithelium
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2023Epithelial metabolism in the intestine is increasingly known to be important for stem cell maintenance and activity while also affecting weight gain and diseases. This review compiles studies from recent years which describe major transcription factors controlling metabolic activity across the intestinal epithelium as well as transcriptional and ...
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Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors
Biochemical and Biophysical Research Communications, 2012Autophagy has been demonstrated to be associated with the pathogenesis of cancer, but no consensus has been reached about its precise role. Therefore, we investigated whether autophagy in the intestinal epithelium is involved in the pathogenesis of intestinal tumors. To evaluate the relationship between autophagy and intestinal tumors, GFP-LC3-APC(min/+
Shin, Nishiumi +5 more
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Intestinal intraepithelial lymphocytes preferentially repopulate the intestinal epithelium
International Immunology, 1993We have used C.B-17 severe combined immune deficiency (SCID) mice to study the repopulation of intestinal intraepithelial cells in these mice. We have found that intestinal intraepithelial lymphocytes (IELs) injected into SCID mice preferentially repopulate the intestinal epithelium.
B C, Sydora, S, Habu, M, Taniguchi
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Functional Relevance of Activin A in the Intestinal Epithelium
Scandinavian Journal of Gastroenterology, 2002Activin A modulates inflammation and repair in various tissues. The aim of this study was to characterize the effects of activin A on intestinal epithelial cell function and to evaluate a potential role in intestinal epithelial wound repair and inflammation.The expression of activin A and its receptors ActRI and ActRII in intestinal epithelial IEC-6 ...
A U, Dignass +3 more
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