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Stem cells of small intestinal epithelium

Bulletin of Experimental Biology and Medicine, 2008
Intestinal epithelium is a rapidly proliferating tissue and represents a unique model for the study of somatic stem cells. Here we summarized the data about markers, main properties, and methods of isolation of intestinal epithelial cells. Some aspects of molecular biology of the intestine are also discussed.
L A, Vedina   +3 more
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DNA synthesis in irradiated intestinal epithelium

Experimental Cell Research, 1960
Abstract 1. 1. DNA synthesis in the intestinal epithelium of X-irradiated mice was studied by means of autoradiography following labeling with tritiated thymidine. Radiation doses used varied from 200 to 3000 rads whole-body irradiation. The label was administered once or 5 times, at times ranging from one day before to 3 days after irradiation ...
F G, SHERMAN, H, QUASTLER
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A quantitative description of the intestinal epithelium of the mouse

American Journal of Anatomy, 1970
AbstractThe use of combined cell kinetic, tritiated thymidine labeling and liquid scintillation counting techniques has permitted quantification of several intestinal epithelial cell parameters. Wet weight and/or whole intestinal values for the following were obtained in C57B1/6 mice.
Hagemann, R F, Sigdestad, C P, Lesher, S
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Formation and loss of dna in intestinal epithelium

Journal of Cell Science, 1969
ABSTRACT The hypothesis that all nuclei containing labelled DNA in the jejunum of adult mice divide before migrating into the villi and that the amount of labelled DNA is constant during the passage of cells through the villi was tested experimentally.
T C, Appleton, S R, Pelc, M H, Tarbit
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Localization of the ‘Sugar Pump’ in the Intestinal Epithelium

Nature, 1961
GLUCOSE is actively transported across the intestinal epithelium from the lumen of the gut into the blood in vivo or into the fluid surrounding the serosal mesothelium in vitro. Because part of the glucose is metabolized during transport, it is not possible to determine the concentration of the unaltered sugar in the various layers of the intestine ...
T Z, CSAKY, G W, FERNALD
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Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

Annual Review of Physiology, 2016
The enteroendocrine system orchestrates how the body responds to the ingestion of foods, employing a diversity of hormones to fine-tune a wide range of physiological responses both within and outside the gut. Recent interest in gut hormones has surged with the realization that they modulate glucose tolerance and food intake through a variety of ...
Fiona M. Gribble, Frank Reimann
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Interactions between lipopolysaccharide and the intestinal epithelium

Journal of the American Veterinary Medical Association, 2004
I ischemia often results in endotoxemia, and endotoxemia significantly increases postoperative morbidity and mortality rates in patients with ischemic intestinal disease. Even if all grossly ischemic intestine is resected, remaining intestine may be injured as a result of distention.
Julia E, Tomlinson   +1 more
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Gate-keeper function of the intestinal epithelium

Beneficial Microbes, 2013
There is currently a major focus on the role of the gut barrier function in balancing mucosal immune responses. Increased epithelial permeability for exogenous antigens is a crucial primary or secondary event in the pathogenesis of several disorders affecting body surfaces and beyond. The epithelial gate-keeper function is determined by the individual'
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Live and let die in the intestinal epithelium

Current Opinion in Cell Biology, 2003
The intestinal epithelium is a relatively simple developmental system and a prime example of tissue renewal from a source of multipotent stem cells. Throughout adulthood, intestinal epithelial proliferation, cell-fate specification and differentiation are coupled to migration in discrete units known as crypts of Lieberkühn.
Sancho, E., Batlle, E., Clevers, J.C.
openaire   +3 more sources

Retroviral Gene Transfer into the Intestinal Epithelium

Human Gene Therapy, 1995
The epithelial cells of the gastrointestinal tract may be attractive targets for somatic gene therapy. In these studies, we have used rats and mice to explore the feasibility of gene transfer into the small intestinal epithelium using retroviral vectors.
Lau, C   +6 more
openaire   +2 more sources

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