Results 71 to 80 of about 12,608,825 (260)
Zebrafish casr modulates cardiac structure and function
Scientific ReportsCalcium is fundamental to biological processes, and the calcium-sensing receptor (CaSR) is pivotal for maintaining calcium homeostasis. Dysregulation of CaSR is implicated in cardiovascular diseases and cancers.
Ling Liu +8 more
doaj +1 more source
The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation
Cells, 2020 The human intestine is covered by epithelium, which is continuously replaced by new cells provided by stem cells located at the bottom of the glands. The maintenance of intestinal stem cells is supported by a niche which is composed of several signaling ...
Sepideh Fallah, Jean-François Beaulieu
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Intestinal barrier function and absorption in pigs after waeaning: a review [PDF]
, 2011 Under commercial conditions, weaning of piglets is associated with social, environmental and dietary stress. Consequently, small-intestinal barrier and absorptive functions deteriorate within a short time after weaning.
Wijtten, P.J.A. +2 more
core +1 more source
MicrobiomeBackground Probiotics have been widely used for the regulation of intestinal health. Current screening methods for probiotics typically rely on animal or two-dimensional cell models. In this study, we employed intestinal organoids to identify a candidate
Yitong Zhang +8 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Phosphate-solubilizing function of Pediococcus pentosaceus PSM16 and its underlying mechanism
Microbiology SpectrumPhosphorus is a crucial nutrient for plant growth, but only a limited quantity is typically accessible in the soil for plants to absorb directly. Phosphate-solubilizing bacteria (PSB) can convert inorganic phosphorus compounds into forms that are more ...
Hong Yaling +15 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2020 The gut is an immune-microbiome-epithelial complex. Gut microbiome-host interactions have widespread biological implications, and the role of this complex system extends beyond the digestion of food and nutrient absorption.
김성은
core +1 more source
Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. [PDF]
, 2009 BACKGROUND: The HIV epidemic in sub-Saharan Africa has had a major impact on infectious disease, and there is currently great interest in the impact of HIV on intestinal barrier function.
Feldman, RA +39 more
core +2 more sources