Results 51 to 60 of about 557,855 (166)

The impact of the intestinal microbiome on bone health

Intractable & Rare Diseases Research, 2018
Intestinal microbial flora, known as the second gene pool of the human body, play an important role in immune function, nutrient uptake, and various activities of host cells, as well as in human disease. Intestinal microorganisms are involved in a variety of mechanisms that affect bone health.
Zhang, Jian, Lu, Yanqin, Wang, Yanzhou, Ren, Xiuzhi, Han, Jinxiang   +4 more
openaire   +3 more sources

The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway

Cells
Ezrin, expressed by the EZR gene, is a member of the ERM protein family that connects the plasma membrane to the actin cytoskeleton, participating in processes such as cell adhesion, migration, and signaling.
Jinrui Lv, Ting Zeng, Beiya Liao, Ling Liu, Lei Xiong, Hao Xie, Lin Zhu, Xingzi Jiang, Zhuchuyu Zhong, Huaping Xie   +9 more
doaj   +1 more source

Early diagnosis and follow-up of cerebrotendinous xanthomatosis in infant siblings presenting with congenital diarrhea: A case study from Saudi Arabia

Molecular Genetics and Metabolism Reports
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive neurometabolic genetic disease resulting from defects in the bile acid metabolism. This report describes cases diagnosed with CTX at an exceptionally early age – 4 months (Patient #2 and #
Badr Mohammad Alsaleem, Amna Basheer Ahmed, Muhannad M. Alruwaithi, Tarig Yassin Alamery, Norah Nasser Alrajhi   +4 more
doaj   +1 more source

MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics

Cell Death and Disease
Endothelial dysfunction contributes to the development of cardiovascular disease in patients with diabetes mellitus, and current strategies remain inadequate.
Jingjing Wei, Ruiwen Mao, Yao Chen, Kunjie Si, Yao Li, Jiaqi Li, Wuzheng Zhu   +6 more
doaj   +1 more source

Intestinal Mononuclear Phagocytes in Health and Disease

Microbiology Spectrum, 2017
ABSTRACT The intestine is the tissue of the body with the highest constitutive exposure to foreign antigen and is also a common entry portal for many local and systemic pathogens. Therefore, the local immune system has the unenviable task of balancing efficient responses to dangerous pathogens with tolerance toward beneficial microbiota and ...
Theodore J, Sanders, Ulf, Yrlid, Kevin J, Maloy   +2 more
openaire   +2 more sources

Stress, Inflammation and the Irritable Bowel Syndrome

Canadian Journal of Gastroenterology, 1999
Studies in animals have shown that inflammation of the mucosa of the gastrointestinal tract is accompanied by changes in enteric nerve and smooth muscle function, and in gut motility and sensation.
Stephen M Collins, Giovanni Barbara, Bruce Vallance   +2 more
doaj   +1 more source

Exploring the genomic traits of infant-associated microbiota members from a Zimbabwean cohort

BMC Genomics
Introduction Our understanding of particular gut microbiota members such as Bifidobacterium and Enterococcus in low-middle-income countries remains very limited, particularly early life strain-level beneficial traits.
Taona Emmah Mudhluli, Magdalena Kujawska, Julia Mueller, Angela Felsl, Bastian-Alexander Truppel, Lindsay J. Hall, Inam Chitsike, Exnevia Gomo, Danai Tavonga Zhou   +8 more
doaj   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics
The size of intestinal villi plays a critical role in determining digestive and absorptive functions, directly affecting nutrient digestibility and feed efficiency. Therefore, elucidating the key mechanisms regulating villus development is of significant
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
doaj   +1 more source

Reconsideration of the laminin receptor 67LR in colorectal cancer cells

Biomolecules & Biomedicine
The 67 kDa laminin receptor (67LR) was identified as the first laminin receptor shown to be involved in the carcinogenesis of various cancers, including colorectal cancer.
Gabriel Cloutier, Jean-François Beaulieu   +1 more
doaj   +1 more source

Effects of dietary SID Lys levels on growth performance, carcass traits, muscle composition, blood biochemistry, and colonic volatile fatty acids in growing Ningxiang pigs

Animal Nutrition
The purpose of this study was to explore the effects of changing standardized ileal digestible (SID) Lys levels in the diet on growth performance, carcass traits, meat quality, blood biochemical indices, and colonic volatile fatty acid levels of ...
Zhaobin Wang, Jiaqi Zhang, Chunchun Geng, Xianglin Zeng, Xin Wang, Pengfei Huang, Qiye Wang, Huansheng Yang, Yulong Yin   +8 more
doaj   +1 more source