Results 41 to 50 of about 12,608,825 (260)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

The study of infectious intestinal disease in England: risk factors for cases of infectious intestinal disease with Campylobacter jejuni infection [PDF]

, 2001
This is a case-control study aimed at identifying risk factors for intestinal infection with Campylobacter jejuni. Cases were defined as subjects with diarrhoea occurring in community cohorts or presenting to General Practitioners (GPs) with ...
Rodrigues, L.C., Wall, PG, Hudson, M.J., Cowden, JM, Wall, P.G., Wheeler, JG, Rodrigues, LC, Tompkins, D.S., Sethi, D., Hudson, MJ, Tompkins, DS, Roderick, PJ, Roderick, P.J., Roberts, JA, Wheeler, J.G., Roberts, J.A., Cumberland, P, Cowden, J.M., Sethi, D   +18 more
core   +1 more source

Oral supplementation of Pediococcus pentosaceus SMM847 ameliorates hyperuricemia in rats and alcohol-induced injury in mice

Applied and Environmental Microbiology
Excessive dietary purine intake can lead to hyperuricemia, facilitating the precipitation and deposition of monosodium urate crystals in joints, which subsequently triggers inflammatory cascades leading to gout.
Yuxin Cao, Linfeng Wang, Cailing Ren, Chenxi Li, Yang Liu, Tong Zhang, Mengjiao Luo, Pan Zhao, Ruijuan Li, Jun Fu, Jia Yin   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

End of life ethical decision making. Susan's story

Clinical Nutrition Open Science, 2023
Summary: This paper describes the story of a patient at her end of life because of recurrent peritoneal carcinomatosis and malignant bowel obstruction with the aim of discussing the most significant controversies and challenges that presented for her ...
Humberto Arenas, Claudia Maria Takahashi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An iterative workflow for mining the human intestinal metaproteome [PDF]

, 2011
Background Peptide spectrum matching (PSM) is the standard method in shotgun proteomics data analysis. It relies on the availability of an accurate and complete sample proteome that is used to make interpretation of the spectra feasible.
Vos, W.M., de, Schaap, Peter, Willem M de Vos, Peter J Schaap, Boeren, S., Christian Beauvallet, Rooijers, Koos, Juste Catherine, Joël Doré, Doré Joël, Beauvallet, Christian, Been, M., de, Rooijers, K., de Been Mark, Schaap, P.J., Dore, Joel, Pilar Galan, Boeren Sjef, Beauvallet, C., Koos Rooijers, de Vos, W.M., Kolmeder, C., Schaap Peter J, Kolmeder, Carolin, Boeren, Sjef, de Vos, Willem M., de Been, Mark, Catherine Juste, Kolmeder Carolin, Galan, P., Doré, J., Rooijers Koos, Juste, C., Galan, Pilar, Mark de Been, Galan Pilar, Sjef Boeren, Beauvallet Christian, de Vos Willem M, de Vos, Willem, Juste, Catherine, Schaap, Peter J., de Been, M., Carolin Kolmeder   +43 more
core   +2 more sources

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

mBio, 2020
Human milk oligosaccharides (HMOs) may provide health benefits to infants partly by shaping the development of the early-life intestinal microbiota. In a randomized double-blinded controlled multicentric clinical trial, healthy term infants received ...
Bernard Berger, Nadine Porta, Francis Foata, Dominik Grathwohl, Michèle Delley, Deborah Moine, Aline Charpagne, Léa Siegwald, Patrick Descombes, Philippe Alliet, Giuseppe Puccio, Philippe Steenhout, Annick Mercenier, Norbert Sprenger   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway

Frontiers in Cell and Developmental Biology
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and blood lipid profiles. However, its molecular mechanisms remain largely unexplored.Methods:In this study, we established cobll1a mutant ...
Ting Zeng, Ting Zeng, Jinrui Lv, Jinrui Lv, Jiaxin Liang, Jiaxin Liang, Binling Xie, Binling Xie, Ling Liu, Ling Liu, Yuanyuan Tan, Yuanyuan Tan, Junwei Zhu, Junwei Zhu, Jifan Jiang, Jifan Jiang, Huaping Xie, Huaping Xie   +17 more
doaj   +1 more source