Results 61 to 70 of about 12,608,825 (260)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Vero cytotoxin-producing Escherichia coli in a study of infectious intestinal disease in England. [PDF]

, 2002
An investigation of infectious intestinal disease in England included examination of feces for Vero cytotoxin-producing Escherichia coli (VTEC). Using DNA probe hybridization 27 VTEC strains were identified, 12 were from cases, and of these three ...
Willshaw, G.A., Wheeler, JG, J.G. Wheeler, Wilson, A., A. Wilson, Tompkins, D.S., J. Evans, D.S. Tompkins, T. Cheasty, G.A. Willshaw, Willshaw, GA, Tompkins, DS, H.R. Smith, Evans, J, Cheasty, T, Evans, J., Cheasty, T., Wheeler, J.G., Wilson, A, Smith, HR, Smith, H.R.   +20 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Infectious Intestinal Disease: Public Health & Clinical Guidance [v1.1] [PDF]

, 2012
This aim of this document is to provide guidance on the public health and clinical management of cases of IID. Its aim is to guide the practice of Consultants in Public Health Medicine and General Practitioners as well as Consultants in Clinical ...
Health Protection Surveillance Centre (HPSC)
core  

The Zebrafish miR-183 Family Regulates Endoderm Convergence and Heart Development via S1Pr2 Signaling Pathway

Biomolecules
MicroRNA (miRNA), as a key post-transcriptional regulatory factor, plays a crucial role in embryonic development. The coordination of endoderm cell convergence and cardiac precursor cell (CPC) migration is critical for cardiac tube fusion.
Ting Zeng, Ling Liu, Jinrui Lv, Hao Xie, Qingying Shi, Guifang Tao, Xiaoying Zheng, Lin Zhu, Lei Xiong, Huaping Xie   +9 more
doaj   +1 more source

Effects of dietary energy on growth performance, carcass characteristics, serum biochemical index, and meat quality of female Hu lambs

Animal Nutrition, 2020
This study evaluated the effects of dietary energy levels on growth performance, carcass traits, meat quality, and serum biochemical of female Hu lambs. Seventy female Hu lambs (aged 4 months) were randomly allotted to 5 dietary treatments.
Yancan Wang, Qiye Wang, Chunpeng Dai, Jianzhong Li, Pengfei Huang, Yali Li, Xueqin Ding, Jing Huang, Tarique Hussain, Huansheng Yang   +9 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Dose- and Time-Dependent Effects of Cobalt Chloride Supplementation on Growth Performance and Intestinal Development in Weaned Piglets

Animals
The aim of our study was to evaluate the effect of dietary cobalt chloride (CoCl2) supplementation on diarrhea, growth performance, and intestinal development in post-weaning piglets.
Min Wang, Siqi Li, Xin Wang, Yutong Zeng, Mingming Guo, Zhaobin Wang, Lanmei Yin, Qiye Wang, Jianzhong Li, Huansheng Yang   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source