Results 141 to 150 of about 670,112 (215)
La obesidad es una enfermedad crónica multifactorial y considerada la pandemia del siglo XXI, caracterizada por el exceso de tejido adiposo. En Ecuador, la tasa de obesidad es del 25.6% en mujeres y del 15% en hombres, ubicándose en el puesto 115 de ...
León Arévalo, Miguel Angel +1 more
core
Advanced Science, EarlyView.Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman +11 more
wiley +1 more source
Metabolic syndrome is, in humans, associated with alterations in the composition and localization of the intestinal microbiota, including encroachment of bacteria within the colon’s inner mucus layer.
Melissa C. Kordahi +7 more
core +1 more source
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou +13 more
wiley +1 more source
Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation
Advanced Science, EarlyView.Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Sheng‐Zhong Han +16 more
wiley +1 more source
Advanced Science, EarlyView.Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han +11 more
wiley +1 more source
Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis
Advanced Science, EarlyView.A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao +10 more
wiley +1 more source
Advanced Science, EarlyView.Antimicrobial coatings for high touch surfaces promise infection control but are too often validated only in the lab. This review shows that active‐agent release governs both human toxicity and environmental impact and argues that durability and real‐world performance must be primary design criteria, placing a safe‐and‐sustainable‐by‐design framework ...
Nurshen Mutlu +19 more
wiley +1 more source
Advanced Science, EarlyView.Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng +8 more
wiley +1 more source