Results 51 to 60 of about 170,881 (248)

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Intestinal Microbiota in Hirschsprung Disease

Journal of Pediatric Gastroenterology and Nutrition, 2018
ABSTRACTObjectives:The aim of the study was to characterize the microbiota profiles of patients with Hirschsprung disease (HD) and to evaluate this in relation to postoperative bowel function and the incidence of Hirschsprung‐associated enterocolitis (HAEC).Methods:All patients operated on for HD at our center between 1987 and 2011 were invited to ...
Salonen Anne, Korpela Katri, Kyrklund Kristiina, Neuvonen Malla I., Pakarinen Mikko P., Rintala Risto J., de Vos Willem, Salonen Anne, Korpela Katri, Kyrklund Kristiina, Neuvonen Malla I., Pakarinen Mikko P., Rintala Risto J., de Vos Willem   +13 more
openaire   +3 more sources

Hypergravity disrupts murine intestinal microbiota [PDF]

Scientific Reports, 2019
AbstractDuring spaceflight, organisms are subjected to various physical stressors including modification of gravity (G) that, associated with lifestyle, could lead to impaired immunity, intestinal dysbiosis and thus potentially predispose astronauts to illness.
Corentine Alauzet, Lisiane Cunat, Maxime Wack, Alain Lozniewski, Hélène Busby, Nelly Agrinier, Catherine Cailliez-Grimal, Jean-Pol Frippiat   +7 more
openaire   +2 more sources

Food‐Based Edible Wireless Sensing Device with Isotropic Electromagnetic Response for Gastrointestinal Monitoring

Advanced Materials Technologies, EarlyView.
A sensor is fabricated that reflects electromagnetic waves wirelessly using only edible materials. The substrate is made of edible materials such as sugar and starch, and the electrodes are made of gold. This sensor has isotropic electromagnetic wave characteristics in response to rotation.
Ryosuke Matsuda, Kentaro Tomita, Shion Miura, Michiyuki Satoh, Tetsuo Kan, Hiroaki Onoe   +5 more
wiley   +1 more source

Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients

Canadian Journal of Infectious Diseases and Medical Microbiology, 2023
The intestinal microbiota is an “invisible organ” in the human body, with diverse components and complex interactions. Homeostasis of the intestinal microbiota plays a pivotal role in maintaining the normal physiological process and regulating immune ...
Zhaoyi Pan, Nanping Wu, Changzhong Jin
doaj   +1 more source

Gut Microbiota Comparison Between Intestinal Contents and Mucosa in Mice With Repeated Stress-Related Diarrhea Provides Novel Insight

Frontiers in Microbiology, 2021
Repeated stress-related diarrhea is a kind of functional bowel disorders (FBDs) that are mainly stemming from dysregulation of the microbiota–gut–brain axis mediated by a complex interplay of 5-hydroxytryptophan (5-HT).
Chen-Yang Zhang, Chen-Yang Zhang, Xin-Xin Peng, Hao-Qing Shao, Xiao-Ya Li, Yi Wu, Zhou-Jin Tan, Zhou-Jin Tan   +7 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Enteric opportunistic infections in patients with inflammatory bowel disease receiving biologic therapies: a retrospective cohort study

Gut Pathogens
Background Biologic therapy has improved outcomes in inflammatory bowel disease (IBD) but may predispose patients to enteric opportunistic infections. Asian data comparing infection risk across biologic classes remain scarce.
Ting-Chieh Huang, Tony Kou, Chia-Jung Kuo, Cheng-Hsun Chiu, Tai-Di Chen, Chien-Ming Chen, Jen-Wei Chou, Tien-Yu Huang, Chen-Wang Chang, Cheng-Tang Chiu, Ming-Yao Su, Yu-Bin Pan, Puo-Hsien Le   +12 more
doaj   +1 more source

Spatial heterogeneity of bacterial colonization across different gut segments following inter-species microbiota transplantation

Microbiome, 2020
Background The microbiota presents a compartmentalized distribution across different gut segments. Hence, the exogenous microbiota from a particular gut segment might only invade its homologous gut location during microbiota transplantation. Feces as the
Na Li, Bin Zuo, Shimeng Huang, Benhua Zeng, Dandan Han, Tiantian Li, Ting Liu, Zhenhua Wu, Hong Wei, Jiangchao Zhao, Junjun Wang   +10 more
doaj   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source