Results 91 to 100 of about 613,825 (294)

Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System

Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an ...
Guli Xu, Ishwari Gyawali, Chang Xu, Dan Du, Gang Shu, Pingwen Xu, Jingjing Zhou, Qingyan Jiang, Zewei Ma, Jinping Yang   +9 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Effect of zinc treatment on intestinal motility in experimentally induced diarrhea in rats [PDF]

, 2015
Zinc supplementation is a critical new intervention for treating diarrheal episodes in children. Recent studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions / salts (ORS) can reduce the duration and ...
Akomolafe, RO, Ojabo, CO, Adeniyi, OS, Olaleye, SB, Eru, EU   +4 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Progress of Researches on Relationship between Acu-moxibustion Induced Modulation of Small Intestinal Motility and Autonomic Nervous Activity

针刺研究, 2014
A large body of evidence of clinical and experimental outcomes showed that acupuncture and moxibustion can effectively treat disorders of small intestinal motility.The present article collected related literatures and made an analysis on the correlation ...
ZHANG Na, YU Zhi, XU Bin
doaj   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Secretin targets interstitial cells of Cajal to regulate intestinal contractions

EMBO Reports
Secretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by ...
Allison M Bartlett, Peter J Blair, Kenton M Sanders, Salah A Baker   +3 more
doaj   +1 more source

Colitis-Induced Small Intestinal Hypomotility Is Dependent on Enteroendocrine Cell Loss in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The abdominal discomfort experienced by patients with colitis may be attributable in part to the presence of small intestinal dysmotility, yet mechanisms linking colonic inflammation with small-bowel motility remain largely ...
Zachariah Raouf, Steve N. Steinway, Daniel Scheese, Carla M. Lopez, Johannes W. Duess, Koichi Tsuboi, Maame Sampah, Daphne Klerk, Mahmoud El Baassiri, Hannah Moore, Cody Tragesser, Thomas Prindle, Jr., Sanxia Wang, Menghan Wang, Hee-Seong Jang, William B. Fulton, Chhinder P. Sodhi, David J. Hackam   +17 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Bacterial metabolite effects on intestinal motility

, 2021
Changes in the intestinal microbiome can be affected by an individual's state of health, stress, antibiotics, diet, and geographic location. Published data show that the microbiome affects colonic function and vice versa.
Varga, Luca Anna
core