Results 111 to 120 of about 613,825 (294)

Intestinal Motility after Ileal Pouch-Anal Anastomosis

Canadian Journal of Gastroenterology, 1990
Colectomy, mucosal proctectomy and ileal pouch-anal anastomosis, has become the procedure of choice for carefully selected patients with ulcerative colitis requiring surgery.
Jacques Heppell
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Control of intestinal motility by the Ca 1.2 L‐type calcium channel in mice

, 2006
Wegener J, Schulla V, Koller A, et al. Control of intestinal motility by the Ca 1.2 L‐type calcium channel in mice. The FASEB Journal.
Klugbauer, Norbert, Schulla, Verena, Feil, Robert, Hofmann, Franz, Wegener, Jörg ; https://orcid.org/, Koller, Angela, Wegener, Jörg W., Wegener, JW;Schulla, V;Koller, A;Klugbauer, N;Feil, R;Hofmann, F   +7 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse

, 2009
We investigated the effects of nonselective cyclooxygenase (COX) inhibitors (indomethacin and flunixin meglumine) and selective COX-1 (SC-560) or COX-2 (celecoxib, DUP-398 and NS-697) inhibitors on horse small bowel motility in vitro.
DACASTO, MAURO, GIANTIN, MERY, POZZOLI C, POLI E, PASSERI B, BERTINI S., MENOZZI A, GOBBETTI T, LOPPARELLI, ROSA MARIA, ZULLIAN C, DACASTO M., MENOZZI, Alessandro, GIANTIN M., POLI, Enzo, BERTINI, Simone, LOPPARELLI R. M., POZZOLI, Cristina, ZULLIAN C., PASSERI, Benedetta, GOBBETTI T.   +19 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Small bowel strictures in Crohn's disease:a quantitative investigation of intestinal motility using MR enterography

, 2013
Intestinal stricturing and aberrant small bowel motility are common complications in patients with Crohn's disease (CD) leading to significant morbidity.
Taylor, S A, Atkinson, D, Punwani, S, Halligan, S, Emmanuel, A, Makanyanga, J, Forbes, A, Helbren, E, Windsor, A, Menys, A   +9 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Relationship between coffee concentration and bowel motility using bowel-sound-based stimulus-response plots in healthy individuals

Scientific Reports
Coffee is consumed worldwide and exerts multifaceted physiological effects, yet evidence on its short-term impact on intestinal motility remains inconsistent. We investigated 40-min changes in motility after coffee prepared at three concentrations (weak,
Tatsuya Miyauchi, Takeyuki Haraguchi, Takahiro Emoto, Kenji Takawaki, Megumi Matsudaira, Junichi Inobe   +5 more
doaj   +1 more source

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay [Dataset]

CARD14 is an intracellular NF-κB signaling mediator in the skin, and rare CARD14 variants have been associated with psoriasis and atopic dermatitis. CARD14 is also expressed in intestinal epithelial cells (IEC).
Damme, Eline van, Manils, Joan, Libert, Claude, Viola, Maria Francesca, Carels, Marieke, Aguilera-Lizárraga, Javier, Boeckxstaens, Guy, Haegman, Mira, Cássia Collaço, Rita de, Ley, Steven C., Bosmans, Frank, Afonina, Inna S., Aidarova, Aigerim, Timmermans, Steven, Beyaert, Rudi, Driege, Yasmine, Wiele, Tom van de   +16 more
core   +1 more source