Results 51 to 60 of about 613,825 (294)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Natural history of intestinal failure, investigated through a network-based approach.

, 2003
OBJECTIVES: Intestinal failure (IF) is a condition whose treatment requires advanced knowledge and techniques and a multidisciplinary approach. Intestinal failure is the endpoint of many intestinal diseases and may result in full recovery, in life-long ...
DE MARCO G, FOR THE ITALIAN NATIONAL NETWORK FOR PEDIATRIC INTESTINAL FAILURE, GUARINO, ALFREDO   +2 more
core   +1 more source

Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities

Frontiers in Pharmacology, 2019
Secretory diarrhea, which primarily originates through intestinal pathogens and viruses, is a health burden in many regions worldwide. Enterocyte Cl− channels, as the final step in enterotoxin-induced fluid secretion, constitute an attractive class of ...
Bo Yu, Xiaojuan Zhu, Xinyu Yang, Lingling Jin, Jia Xu, Tonghui Ma, Hong Yang   +6 more
doaj   +1 more source

Short-term intestinal ischemia-reperfusion alters intestinal motility that can be preserved by xanthine oxidase inhibition

, 2002
While the effects of transient intestinal ischemia on mucosa have been well investigated, less is known about its effect on motor function. An experimental study was designed to investigate the effects of ischemia-reperfusion (I/R) on intestinal motility
HAKGÜDER, FAİKA GÜLCE, Ates, O, Akgur, FM, Ozer, E, OLGUNER, MUSTAFA, Aktug, T   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pediatric intestinal pseudo-obstruction: Role of histopathology

Journal of Pediatric Surgery Case Reports, 2020
Pediatric intestinal pseudo-obstruction (PIPO) is a rare and debilitating clinical disorder characterized by gastrointestinal motility dysfunction, resulting in symptoms suggestive of total or partial intestinal obstruction in the absence of any lumen ...
Ana Luiza Melo dos Santos, Rafaela Wander Almeida Braga, Heinrich Bender Kohnert Seidler, Rodrigo Pinheiro de Abreu Miranda, Ivânia Itália Teixeira Salvador, Elisa de Carvalho   +5 more
doaj   +1 more source

American Neurogastroenterology and Motility Society (ANMS) Task Force Recommendations for Resumption of Motility Laboratory Operations During the COVID-19 Pandemic [PDF]

, 2020
The ANMS organized a Task Force for developing guidance strategies regarding re-opening of motility laboratories. This document describes how to stratify urgency of motility physiologic procedures, screen prior to the procedures, optimize personal ...
Gyawali, C. Prakash, Neshatian, Leila, Nguyen, Linda, Baker, Jason R., Rao, Satish, Garza, Jose, Saad, Richard, Khan, Abraham R., Pandolfino, John E., Moshiree, Baha, Chey, William D., Waseem, Shamaila   +11 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Potential of nutraceutical products for irritable bowel syndrome remission maintenance

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of review. To summarize the modern data on pathogenesis of symptoms irritable bowel syndrome (IBS) symptoms, to present nutraceutical product «Standart zdorovya: GASTRO» as an agent for IBS remission maintenance. Summary.
A. I. Ulyanin, Ye. A. Poluektova, Ch. S. Pavlov, V. T. Ivashkin   +3 more
doaj   +1 more source