Results 201 to 210 of about 215,029 (331)

Larazotide Acetate Protects the Intestinal Mucosal Barrier from Anoxia/Reoxygenation Injury via Various Cellular Mechanisms. [PDF]

Biomedicines
Kim J, Madan JP, Laumas S, Krishnan BR, Jin Y.   +4 more
europepmc   +1 more source

Wirelessly Powered Soft Magnetic Robot with Microneedle for Electrical Stimulation and Drug Delivery

Advanced Intelligent Systems, EarlyView.
A wirelessly powered soft magnetic robot integrates microneedles to enable dual functions: electrical stimulation (86.7% efficiency at 6 cm, tunable 0–20 V voltage, 0.4–50 ms pulses) and drug delivery. It switches surfaces via magnetic fields for gastrointestinal tract locomotion and treatment, with in vitro validation in fresh pig gut showing ...
Song Zhao, Liwen Zhang, Shengbin Zhang, Botao Ma, Meng Wang, Yipan Zuo, Xinzhao Zhou, Xueshan Jing, Huawei Chen   +8 more
wiley   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Linarin alleviates enterotoxigenic Escherichia coli-induced small intestinal mucosal barrier damage in a piglet model by modulating the gut microbiota. [PDF]

Anim Microbiome
Wang M, Liu X, Ji X, Wen A, Wang H, Jin E, Zhang F.   +6 more
europepmc   +1 more source

Micro/Nanorobot for Drug Delivery—A Review of Material Selections

Advanced NanoBiomed Research, EarlyView.
This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley   +1 more source

Metformin May Improve Intestinal Mucosal Barrier Function and Help Prevent and Reverse Colorectal Cancer in Mice. [PDF]

J Cancer
Wang R, Xie L, Jiang P, Hou Y, Li D, Wang W.   +5 more
europepmc   +1 more source

Severe hepatitis and intestinal mucosal barrier

World Chinese Journal of Digestology, 2010
Zhi-Yun Deng, Ti-Dong Shan, Fang-Xin Zhang   +2 more
openaire   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Yuyang Decoction Regulates Macrophage Polarization and Repairs the Intestinal Mucosal Barrier via the TLRs/Tollip Signaling Pathway. [PDF]

J Inflamm Res
Lian J, Jin G, Li J, Zhang W, Chang Y, Li W, Zhi H, Tian J, Liang C, Su J.   +9 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source