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The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases
Biomolecules, 2022 Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for the maintenance of the normal physiological functions of cells and organisms. The intestine is the main location for zinc absorption and excretion, while zinc and zinc homeostasis is also of great significance to the structure and function of the intestinal ...
Bingkun Zhang, Zhang Bingkun
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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Nature Reviews Microbiology, 2018 The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection.
Eric C Martens +2 more
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Reviews in Fish Biology and Fisheries, 2020 The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier.
Tsegay Teame +2 more
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The role of autophagy in maintaining intestinal mucosal barrier
Journal of Cellular Physiology, 2019AbstractThe intestinal mucosal barrier is the first line to defense against luminal content penetration and performs numerous biological functions. The intestinal epithelium contains a huge surface that is lined by a monolayer of intestinal epithelial cells (IECs).
Baikui Wang, Qiming Sun, Weifen Li
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Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Journal of Inflammation Research, 2021 Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet cells and mucus has changed, with current evidence suggesting that they are not passive but play a positive role in maintaining intestinal tract immunity and mucosal ...
Songwei Yang, Min Yu
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Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier
Trends in Immunology, 2018 Intestinal intraepithelial lymphocytes (IELs) are a large and diverse population of lymphoid cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal barrier. Although IEL biology has traditionally focused on T cells, recent studies have identified several subsets of T cell receptor (TCR)-negative IELs with ...
Danyvid Olivares-Villagómez +1 more
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Intestinal mucosal barrier function in health and disease
Nature Reviews Immunology, 2009Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier.
Jerrold R Turner, Turner Jerrold R
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HIV infection and the intestinal mucosal barrier
Annals of the New York Academy of Sciences, 2012HIV infection induces a barrier defect of the intestinal mucosa, which is closely linked to immune activation and CD4 T cell depletion. The HIV‐induced barrier defect is initiated in early acute and maintained through chronic infection. In acute infection, increased epithelial permeability is associated with increased epithelial apoptosis possibly ...
Hans-Jörg, Epple, Martin, Zeitz
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Intestinal Inflammation and Mucosal Barrier Function
Inflammatory Bowel Diseases, 2014Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions ...
Fermín, Sánchez de Medina +3 more
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Bacterial chemotactic oligopeptides and the intestinal mucosal barrier
Gastroenterology, 1989Intestinal absorption and enterohepatic circulation of N-formyl-methionyl-leucyl-125I-tyrosine, a bioactive synthetic analog of the bacterial chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine has been investigated in the rat. In ileum and proximal and distal colon, dithiothreitol, which increases mucosal permeability, increased peptide ...
D M, Ferry +4 more
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