Results 251 to 260 of about 86,263 (270)

Unique characteristics of the neonatal intestinal mucosal barrier

Journal of Pediatric Surgery, 1992
The purpose of this study was to compare the newborn and weanling intestinal mucosa to determine differences in: (1) the electrophysiologic characteristics of the mucosal barrier; (2) the effects of glutamine supplementation on these physiological characteristics; and (3) transmucosal bacterial passage. The Ussing chamber was used to study ileal mucosa
S D, Smith, M A, Cardona, S A, Wishnev, A G, Kurkchubasche, M I, Rowe   +4 more
openaire   +2 more sources

Disruption of the intestinal mucosal barrier in Candida albicans infections

Microbiological Research, 2013
Candida albicans is a common microorganism in the intestine. However, invasive C. albicans infection has emerged as a life-threatening disease in recent years. The mortality rate of invasive candidiasis is high in critically ill hosts. C. albicans can switch from the yeast to the hyphal morphology, and take advantage of the impaired intestinal mucosal ...
Jianguo Tang
exaly   +3 more sources

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

Clinical Anatomy, 2023
AbstractRheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical barrier, immune barrier, and microflora barrier.
Jing, Li, Nini, Jia, Mengyao, Cui, Yaqing, Li, Xiang, Li, Xiaoqin, Chu   +5 more
openaire   +2 more sources

Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis

Digestive Diseases and Sciences, 2004
Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate the small intestine barrier function and electrolyte ...
B A, Carneiro-Filho, I P F, Lima, D H, Araujo, M C, Cavalcante, G H P, Carvalho, G A C, Brito, V, Lima, S M N, Monteiro, F N, Santos, R A, Ribeiro, A A M, Lima   +10 more
openaire   +2 more sources

Effects of Hypoperfusion on Small-Intestinal Mucosal Morphology and Intestinal Barrier Function

Scandinavian Journal of Gastroenterology, 1996
Our aim was to evaluate in vitro perfusion of the rat small intestine as a method to study the pathophysiology of hypoperfusion and to minimize its adverse effects.Rat small intestine was perfused for 24 h using RPMI + albumin for the lumen and RPMI + erythrocyte concentration (Hct 20%) in the vasculature, at 22 degrees C, 15 degrees C, 10 degrees C ...
G, Kurlberg, K, Lundholm, E, Haglind
openaire   +2 more sources

Intestinal mucosal epithelium: the barrier to sepsis

Journal of Organ Dysfunction, 2006
The intestinal epithelium provides a critical barrier to pathogens and their toxins within the intestinal lumen. The epithelium is capable of directly interacting with intestinal pathogens such as Salmonella species, resulting in a release of cytokines beneath the epithelium that likely play a role in sepsis.
openaire   +1 more source

Regulatory Effect of Histamine on the Barrier Function of Intestinal Mucosal

Journal of Gastrointestinal Surgery, 2010
To investigate the regulatory effect of histamine on the barrier function of intestinal mucosal.The monolayer Caco-2 cell system in vitro and the model of hemorrhage infection in rats in vivo were established as experimental models. The amount of bacterial translocation was taken as an index of the effect of histamine and its receptor antagon ...
Ligeng, Duan, Xiaoli, Chen, J W, Alexander   +2 more
openaire   +2 more sources

NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

Physiology, 2015
The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier.
Anne-Kathrin, Claes, Jun Yu, Zhou, Dana J, Philpott   +2 more
openaire   +2 more sources

Roles of the Epithelial Autophagy in the Intestinal Mucosal Barrier

2016
Intestines are a part of the gastrointestinal tract and essential for digestion and absorbtion of food. It is also home to a dense community of resident bacteria and exposed to a very large number of microorganisms associated with food and from the external environment.
Koji Aoki, Manabu Sugai
openaire   +1 more source

Protective mechanism of Bifidobacterium on intestinal mucosal barrier in sepsis

Microbial Pathogenesis
Prior research has examined the advantageous impacts of probiotics in preventing and treating sepsis; however, the protective actions of Bifidobacterium against sepsis are still not understood. In this review, we innovatively discussed the mechanisms by which Bifidobacterium can prevent and treat sepsis by regulating the intestinal mucosal barrier ...
Kai-Jun, Zhang, Yi-Feng, Chang, Yi-Fan, Liu, Shi-Xue, Dai, Jie, Li   +4 more
openaire   +2 more sources