Results 291 to 300 of about 215,029 (331)

Colonic interleukin‐22 protects intestinal mucosal barrier and microbiota abundance in severe acute pancreatitis

The FASEB Journal, 2022
Intestinal barrier dysfunction plays a critical role in the pathophysiology of many diseases including severe acute pancreatitis (SAP). Interleukin‐22 (IL‐22) is a critical regulator of intestinal epithelial homeostasis.
Meng Jin, Huimin Zhang, Meixu Wu, Zheng Wang, Xuan Chen, M. Guo, R. Zhou, Hong Yang, J. Qian   +8 more
semanticscholar   +1 more source

A critical review on intestinal mucosal barrier protection effects of dietary polysaccharides.

Food & Function
Studies have shown that dietary polysaccharides, which are widely present in natural foods, have an important impact on the intestinal mucosal barrier. Dietary polysaccharides can maintain the intestinal barrier function through multiple mechanisms.
Weiqi Yan, Jinhai Luo, Zhiling Yu, Baojun Xu   +3 more
semanticscholar   +1 more source

Impact of nanomaterials on the intestinal mucosal barrier and its application in treating intestinal diseases.

Nanoscale Horizons, 2021
The intestinal mucosal barrier (IMB) is one of the important barriers to prevent harmful substances and pathogens from entering the body environment and to maintain intestinal homeostasis. The dysfunction of the IMB is associated with intestinal diseases
Wenshuai Hao, Ruitao Cha, Mingzheng Wang, Pai Zhang, Xingyu Jiang   +4 more
semanticscholar   +1 more source

Bacterial chemotactic oligopeptides and the intestinal mucosal barrier

Gastroenterology, 1989
Intestinal absorption and enterohepatic circulation of N-formyl-methionyl-leucyl-125I-tyrosine, a bioactive synthetic analog of the bacterial chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine has been investigated in the rat. In ileum and proximal and distal colon, dithiothreitol, which increases mucosal permeability, increased peptide ...
D M, Ferry, T J, Butt, M F, Broom, J, Hunter, V S, Chadwick   +4 more
openaire   +2 more sources

NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

Physiology, 2015
The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier.
Anne-Kathrin, Claes, Jun Yu, Zhou, Dana J, Philpott   +2 more
openaire   +2 more sources

Unique characteristics of the neonatal intestinal mucosal barrier

Journal of Pediatric Surgery, 1992
The purpose of this study was to compare the newborn and weanling intestinal mucosa to determine differences in: (1) the electrophysiologic characteristics of the mucosal barrier; (2) the effects of glutamine supplementation on these physiological characteristics; and (3) transmucosal bacterial passage. The Ussing chamber was used to study ileal mucosa
S D, Smith, M A, Cardona, S A, Wishnev, A G, Kurkchubasche, M I, Rowe   +4 more
openaire   +2 more sources

The intestinal mucosal barrier – A key player in rheumatoid arthritis?

Clinical Anatomy, 2023
AbstractRheumatoid arthritis (RA) is a recurrent chronic autoimmune disease, which is not only difficult to treat, but also has a great adverse impact on the physical and mental health of patients. The intestinal mucosa barrier has some relationship with RA and it consists of mechanical barrier, chemical barrier, immune barrier, and microflora barrier.
Jing, Li, Nini, Jia, Mengyao, Cui, Yaqing, Li, Xiang, Li, Xiaoqin, Chu   +5 more
openaire   +2 more sources

Intestinal Barrier Function and Secretion in Methotrexate-Induced Rat Intestinal Mucositis

Digestive Diseases and Sciences, 2004
Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate the small intestine barrier function and electrolyte ...
B A, Carneiro-Filho, I P F, Lima, D H, Araujo, M C, Cavalcante, G H P, Carvalho, G A C, Brito, V, Lima, S M N, Monteiro, F N, Santos, R A, Ribeiro, A A M, Lima   +10 more
openaire   +2 more sources

The role of autophagy in maintaining intestinal mucosal barrier

Journal of Cellular Physiology, 2019
AbstractThe intestinal mucosal barrier is the first line to defense against luminal content penetration and performs numerous biological functions. The intestinal epithelium contains a huge surface that is lined by a monolayer of intestinal epithelial cells (IECs).
Yanping Wu, Li Tang, Baikui Wang, Qiming Sun, Pengwei Zhao, Weifen Li   +5 more
openaire   +2 more sources

Mucosal Plasma Cell Barrier Disruption During Intestine Transplant Rejection

Transplantation, 2012
Intestinal allograft mucosa undergoes repopulation with host immunocytes. However, critical changes within key immunocyte subsets are not known.To explain acute cellular rejection after intestine transplantation (ITx) on the basis of altered mucosal immunocytes, rejecting and rejection-free ITx allografts (n=17) were compared with genome-wide ...
Mylarappa, Ningappa, Chethan, Ashokkumar, Sarangarajan, Ranganathan, Lori, Schmitt, Brandon W, Higgs, Qing, Sun, Maria, Branca, George, Mazariegos, Adriana, Zeevi, Kareem, Abu-Elmagd, Robert, Squires, Jeffrey, Rudolph, Feras, Alissa, Hakon, Hakonarson, Rakesh, Sindhi   +14 more
openaire   +2 more sources