Results 41 to 50 of about 163,773 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Add-on to current guidelines for monitoring of SBS patients treated with teduglutide

npj Gut and Liver
By inducing growth of the intestinal epithelium, the drug teduglutide, used for the treatment of short bowel syndrome-associated intestinal failure, could feasibly promote growth of pre-existing colonic neoplasms and incite the development of new ones. A
Francisca Joly, Johane P. Allard, Gabriel E. Gondolesi, Palle Bekker Jeppesen, Martina Kohl-Sobania, Ulrich-Frank Pape, Loris Pironi, Lauren K. Schwartz, Joel Mason   +8 more
doaj   +1 more source

Solitary plasmacytoma extramedullary to duodenal level: an unusual case of intestinal occlusion

Galicia Clínica, 2019
Plasma cell neoplasms represent only 1-2% of hematological malignancies and intestinal plasmocytoma represents only 3%. Extramedullary plasmocytomas most commonly are located in upper airway and oral cavity; the gastrointestinal plasmocytoma only ...
Manuel Lorenzo López Reboiro, Inés Navarro Menéndez, Lucía Cid Conde, José López Castro   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Ileocecal intussusception in a patient with ileal melanoma metastasis: clinical case and review of the literature

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of clinical case presentation. Choice of optimal surgical approach for treatment of intestinal intussusception. Key points. Intestinal intussusception is a rare condition, especially in adults, which can develop due to both benign and malignant ...
M. A. Danilov, A. O. Atroschenko, S. V. Pozdnyakov, G. G. Saakyan   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer in patients under age 50: a five-year experience

Revista do Colégio Brasileiro de Cirurgiões
Objective : to evaluate the clinical characteristics of patients with colorectal cancer under the age of 50 treated at a public hospital in Brasilia over 5 years.
FERNANDO MARINHO MARQUES DA SILVA, ROBERTA PAIVA DUARTE, CÁSSIO CÉSAR ARRAIS LEÃO, CAROLINA MARTINS VISSOCI, AMANDA LUÍZA AGUIAR TAQUARY ALVARENGA, ANNA BEATRIZ SALLES RAMOS, AMANDA EVELYN CRUVINEL GOULART   +6 more
doaj   +1 more source

Intestinal obstruction caused by neoplasms in two cows

Ciência Rural, 2016
: In cattle, abdominal tumors leading to partial or total intestinal obstruction are rare. Here, it is described the clinico-pathological findings of two cows with intestinal obstruction by neoplasms.
Antônio Carlos Lopes Câmara, Márcio Botelho de Castro, Eraldo Barbosa Calado, Benito Soto-Blanco   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source