Results 11 to 20 of about 49,154 (113)

The Effects of Rapamycin on the Intestinal Graft in a Rat Model of Cold Ischemia Perfusion and Preservation

Metabolites, 2022
Attenuating the rheological and structural consequences of intestinal ischemia-reperfusion-injury (IRI) is important in transplant proceedings. Preconditioning is an often-proposed remedy.
Ibitamuno Caleb, Benedek Kasza, Luca Erlitz, Dávid Semjén, Péter Hardi, Lilla Makszin, Szilárd Rendeki, Ildikó Takács, Tibor Nagy, Gábor Jancsó   +9 more
doaj   +1 more source

Applications of indocyanine greenenhanced fluorescence in the laparoscopic treatment of colonic stricture after necrotizing enterocolitis

BMC Pediatrics, 2023
Background The status of anastomotic blood perfusion is associated with the occurrence of anastomotic leakage after intestinal anastomosis. Fluorescence angiography (FA) with indocyanine green (ICG) can objectively assess intestinal blood perfusion. This
Xiaohong Die, Mengying Cui, Wei Feng, Jinfeng Hou, Pengfei Chen, Wei Liu, Fang Wu, Zhenhua Guo   +7 more
doaj   +1 more source

Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani, Mohammed A. Al-Khawlani, Anes A.M. Thabet   +2 more
doaj   +1 more source

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Pharmaceutics, 2020
Permeation enhancers like sodium dodecyl sulfate (SDS) and caprate increase the intestinal permeability of small model peptide compounds, such as enalaprilat (349 Da).
David Dahlgren, Markus Sjöblom, Mikael Hedeland, Hans Lennernäs   +3 more
doaj   +1 more source

Real-time quantification of bowel perfusion using Laparoscopic Laser Speckle Contrast Imaging (LSCI) in a porcine model

BMC Surgery, 2023
Background/purpose Real-time quantification of tissue perfusion can improve intraoperative surgical decision making. Here we demonstrate the utility of Laser Speckle Contrast Imaging as an intra-operative tool that quantifies real-time regional ...
Saloni Mehrotra, Yao Z. Liu, Chibueze A. Nwaiwu, Vasiliy E. Buharin, Roman Stolyarov, Steven D. Schwaitzberg, Matthew F. Kalady, Peter C. W. Kim   +7 more
doaj   +1 more source

L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL

Transplantation Reports, 2022
Background: The small intestine is one of the most sensitive organs to ischemia. L-arginine has been shown to reduce damage from ischemia and reperfusion injury.
Michele Finotti, Maria Barahona, Renee M. Maina, Taras Lysyy, Raghav Agarwal, Phillip Schmitt, Giorgio Caturegli, Chiara Di Renzo, Alessandro Anselmo, David Mulligan, John P. Geibel, Francesco D'Amico   +11 more
doaj   +1 more source

Elevated pulsatility index of the superior mesenteric artery indicated prolonged mechanical ventilation in patients after cardiac valve surgery

Frontiers in Surgery, 2023
PurposeThis study examined whether alterations in Doppler parameters of superior mesenteric artery (SMA) are associated with prolonged mechanical ventilation (PMV) in patients who underwent cardiac valve surgery.MethodsHemodynamic and SMA Doppler ...
Yuankai Zhou, Huaiwu He, Na Cui, Xiaoting Wang, Yun Long, Dawei Liu   +5 more
doaj   +1 more source

Use of near-infrared imaging using indocyanine green associates with the lower incidence of postoperative complications for intestinal and mesenteric injury

Scientific Reports, 2021
Anastomotic leakage after intestinal resection is one of the most serious complications of surgical intervention for hollow viscus injury. Adequate vascular perfusion of the anastomotic site is essential to prevent anastomotic leakage.
Keishi Yamaguchi, Takeru Abe, Kento Nakajima, Chikara Watanabe, Yusuke Kawamura, Hirokazu Suwa, Yuta Minami, Kazunori Nojiri, Hidetaka Ono, Kenichi Yoshida, Hidenobu Masui, Tomoki Doi, Ichiro Takeuchi   +12 more
doaj   +1 more source

Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates

Journal of the Formosan Medical Association, 2008
First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho, Ming-Yen Lai, Hsiu-Ying Yu, Da-Kong Huang, Wei-Cherng Hsueh, Tung-Hu Tsai, Chia-Chun Lin   +6 more
doaj   +1 more source

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Pharmaceutics, 2020
Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model.
David Dahlgren, Maria-Jose Cano-Cebrián, Tobias Olander, Mikael Hedeland, Markus Sjöblom, Hans Lennernäs   +5 more
doaj   +1 more source