Results 21 to 30 of about 18,329 (193)

Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. [PDF]

PLoS ONE, 2015
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas.
Joshua S Son, Shanawaj Khair, Donald W Pettet, Nengtai Ouyang, Xinyu Tian, Yuanhao Zhang, Wei Zhu, Gerardo G Mackenzie, Charles E Robertson, Diana Ir, Daniel N Frank, Basil Rigas, Ellen Li   +12 more
doaj   +1 more source

Colonic Polyps in Children and Adolescents

Canadian Journal of Gastroenterology, 2007
Colonic polyps most commonly present with rectal bleeding in children. The isolated juvenile polyp is the most frequent kind of polyp identified in children.
Carol A Durno
doaj   +1 more source

Serrated Polyposis Syndrome with a Synchronous Colon Adenocarcinoma Treated by an Endoscopic Mucosal Resection

The Korean Journal of Gastroenterology, 2020
Serrated polyposis syndrome (SPS) can transform to malignant lesions through the sessile serrated pathway and traditional serrated pathway. These pathways may cause rapid neoplastic progression compared to the adenoma-carcinoma sequence, which may cause ...
Sang Hoon Lee, Sung Joon Lee, Sung Chul Park, Seung-Joo Nam, Myeong Ho Kang, Tae Suk Kim, Seung Koo Lee   +6 more
doaj   +1 more source

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. [PDF]

PLoS Genetics, 2009
Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra ...
Claudia Gaspar, Patrick Franken, Lia Molenaar, Cor Breukel, Martin van der Valk, Ron Smits, Riccardo Fodde   +6 more
doaj   +1 more source

Antibiotic‐mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus‐producing goblet cells and increased colorectal cancer progression

Cancer Medicine, 2018
Recent epidemiological evidence suggests that exposure to antibiotics in early‐to‐middle adulthood is associated with an increased risk of colorectal adenoma.
Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L. O'Brien, Nadim J. Ajami, Thomas A. Auchtung, Joseph F. Petrosino, Alexander‐Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M. Gummadidala, Mayomi H. Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G. Berger, James A. Carson, Anindya Chanda   +18 more
doaj   +1 more source

Extensive colorectal lymphomatous polyposis complicated by acute intestinal obstruction: a case report

Journal of Medical Case Reports, 2017
Background Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle ...
Jaques Waisberg, Amanda do Val Anderi, Pedro Augusto Soffner Cardoso, José Henrique Miranda Borducchi, Demetrius Eduardo Germini, Maria Isete Fares Franco, Cidia Vasconcellos   +6 more
doaj   +1 more source

Hereditary colorectal cancer syndromes [PDF]

Iranian Journal of Colorectal Research, 2020
Context: In recent decades there has been an increase in hereditary colorectal cancer cases in people under 50 years of age. Several studies revealed similar pathologies with both molecular and clinical variations about hereditary colorectal neoplasms ...
Fernanda Rivera, Yuliana Mendoza, Heriberto Medina   +2 more
doaj   +1 more source

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

PLoS Genetics, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Näthke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst   +18 more
doaj   +1 more source

Poliposis linfomatosa intestinal Intestinal lymphomatous polyposis

Medisan, 2009
Se expone el caso clínico de un paciente de 55 años de edad, de piel blanca, que acudió a la consulta de Gastroenterología por presentar diarreas desde hacía alrededor de un año, dolor abdominal difuso, pérdida de peso, astenia y anorexia.
Cesar Falagán Andina, Elba Patricia Cabezas Niubó, Inocente Rodríguez Reyes, Lilibet Zamora Cabezas, Jesús Fernández Duharte   +4 more
doaj   +2 more sources

Small Bowel Tumors and Polyposis: How to Approach and Manage?

The Korean Journal of Gastroenterology, 2018
Although small bowel the mainly occupies the most part of the gastrointestinal tract, small intestine tumors are rare, insidious in clinical presentation, and frequently represent a diagnostic and management challenge.
Bong Min Ko
doaj   +1 more source