Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. [PDF]
PLoS ONE, 2014 Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (
Bin Li +13 more
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Cowden syndrome - Diagnostic skin signs [PDF]
, 2001 Cowden syndrome is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. The most important clinical features include carcinomas of the breast and thyroid, and hamartomatous polyps of the gastrointestinal tract.
Burgdorf, Walter H. C. +2 more
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Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
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The Somatic Mutation Hit on Top of Genetic APC mutations Cause Skin Tumor
Translational Oncology, 2020 Inactivation of the adenomatous polyposis coli (APC) gene is the initiating event in familial adenomatous polyposis (FAP) patients. Up to 90% of FAP patients show intestinal tumors and other extracolonic malignancies including hepatoblastomas, desmoid ...
Ting Niu +8 more
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Diagnostic imaging and CEUS findings in a rare case of Desmoid-type fibromatosis. A case report [PDF]
, 2018 Desmoid-type fibromatosis (DF), also known as aggressive fibromatosis, is a locally aggressive benign fibroblastic neoplasm that can infiltrate or recur but cannot metastasize.
De Felice, Carlo +6 more
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Peutz-Jeghers Syndrome without Polyposis
Canadian Journal of Gastroenterology, 1988 Peutz-Jeghers syndrome is generally considered a condition in which familial gastrointestinal polyposis is associated with a characteristic pigmentation of the skin and mucous membranes Two members of a family in which the characteristic pigmentation was
Anthony G. Catto-Smith +2 more
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Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. [PDF]
PLoS ONE, 2015 Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas.
Joshua S Son +12 more
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Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. [PDF]
, 2015 BackgroundAdenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in ...
Bellusci, Saverio +9 more
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A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. [PDF]
PLoS Genetics, 2009 Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra ...
Claudia Gaspar +6 more
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Colonic Polyps in Children and Adolescents
Canadian Journal of Gastroenterology, 2007 Colonic polyps most commonly present with rectal bleeding in children. The isolated juvenile polyp is the most frequent kind of polyp identified in children.
Carol A Durno
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