Results 31 to 40 of about 402,657 (223)

Gardner syndrome with giant abdominal desmoid tumor during pregnancy: a case report

BMC Surgery, 2020
Background Gardner syndrome is a subtype of familial adenomatous polyposis (FAP), characterized by a combination of adenomatous intestinal polyps and extracolonic lesions such as multiple osteomas, dental abnormalities, and soft tissue tumors.
Liquan Jin, Yunbo Tan, Ziting Su, Shan Huang, Sita Pokhrel, Hongbo Shi, Yiming Chen   +6 more
doaj   +1 more source

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. [PDF]

, 2010
E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Trülzsch, Konrad, Eckhard Wolf, Sylvia Steininger, Hirschi Benjamin, Müller-Höcker Josef, Frank T Kolligs, Allgäuer, Michael, Marlon R. Schneider, Schneider Marlon R., Dahlhoff, Maik, Gerhard Markus, Schneider, Marlon R., Konrad Trülzsch, Vogelmann, Roger, Maik Dahlhoff, Müller-Höcker, Josef, Michael Allgäuer, Allgäuer Michael, Horst David, Roger Vogelmann, Markus Gerhard, Horst, David, Frank T. Kolligs, Wolf Eckhard, Dahlhoff Maik, Benjamin Hirschi, Kolligs, Frank T., David Horst, Trülzsch Konrad, Wolf, Eckhard, Josef Müller-Höcker, Kolligs Frank T., Marlon R Schneider, Hirschi, Benjamin, Steininger Sylvia, Gerhard, Markus, Steininger, Sylvia, Vogelmann Roger   +37 more
core   +1 more source

CLINICAL, EPIDEMIOLOGIC, AND ENDOSCOPIC PROFILE IN CHILDREN AND ADOLESCENTS WITH COLONIC POLYPS IN TWO REFERENCE CENTERS

Arquivos de Gastroenterologia, 2015
Background - The main goal of this paper is to investigate the frequency, clinical profile, and endoscopic findings of children and teenagers submitted to colonoscopies.
Denise O ANDRADE, Alexandre Rodrigues FERREIRA, Paulo Fernando S BITTENCOURT, Daniela F P RIBEIRO, Rodrigo Gomes da SILVA, Luiz Ronaldo ALBERTI   +5 more
doaj   +1 more source

Gene expression analyses on skin lesions from patients with familial adenomatous polyposis [PDF]

, 2014
Familial adenomatous polyposis coli (FAP) is an autosomal dominant colorectal cancer predisposition syndrome caused by germline mutations in the APC gene.
Stegmann, Danielle Alexandra
core   +1 more source

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells. [PDF]

PLoS ONE, 2018
Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis.
Cesar A Sommer, Amalia Capilla, Francisco J Molina-Estevez, Andreia Gianotti-Sommer, Nicholas Skvir, Ignacio Caballero, Sanjib Chowdhury, Gustavo Mostoslavsky   +7 more
doaj   +1 more source

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Newton, Ian P., Clarke, Alan Richard, Jamieson, TJ, Sansom, Owen, Nathke, Inke S.; id_orcid, Alan Clarke, Newton, IP, Clarke, A, Ian P. Newton, Owen Sansom, Thomas J. Jamieson, Dikovskaya, D, Meniel, V, Kroboth, K, Sansom, O, Dikovskaya, Dina, Oakley, A, Oakley, Abigail, Abigail Oakley, Nathke, IS, Schiffmann, D, Valerie Meniel, Clarke, Alan, Schiffmann, David, Kroboth, Karin, David Schiffmann, Nathke, Inke S., Sansom, Owen J., Dina Dikovskaya, Inke S. Näthke, Karin Kroboth, Meniel, Valerie, Jamieson, Thomas J.   +32 more
core   +1 more source

New hereditary polyposis syndromes in the patient with intestinal polyps [PDF]

, 2022
Hereditary polyposis syndromes (HPS) are a group of rare, inherited syndromes characterised by the presence of histopathological specific or numerous intestinal polyps and a high risk of intestinal and extraintestinal cancer.
Jelsig, Anne Marie, Lautrup, Charlotte Kvist, Jespersen, Niels, Sund, Lone, Qvist, Niels, Ketabi, Zohreh, Thorlacius-Ussing, Ole, Karstensen, John Gásdal, Rønlund, Karina, Wadt, Karin   +9 more
core   +2 more sources

Hereditary non-polyposis colorectal carcinoma (HNPCC) : morphological and immunohistochemical studies [PDF]

, 2005
Includes bibliographical references.Families with hereditary non-polyposis colorectal carcinoma (HNPCC) are not uncommon along the West-Coast of South Africa.
Holm, Hannes
core   +1 more source

The Somatic Mutation Hit on Top of Genetic APC mutations Cause Skin Tumor

Translational Oncology, 2020
Inactivation of the adenomatous polyposis coli (APC) gene is the initiating event in familial adenomatous polyposis (FAP) patients. Up to 90% of FAP patients show intestinal tumors and other extracolonic malignancies including hepatoblastomas, desmoid ...
Ting Niu, Mingming Yang, Qing Liu, Haobin Li, Lingbi Jiang, Fanggu Li, Xiaodong He, Lijing Wang, Jiangchao Li   +8 more
doaj   +1 more source

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. [PDF]

PLoS ONE, 2014
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (
Bin Li, Colin A Flaveny, Camilla Giambelli, Dennis Liang Fei, Lu Han, Brian I Hang, Feng Bai, Xin-Hai Pei, Vania Nose, Oname Burlingame, Anthony J Capobianco, Darren Orton, Ethan Lee, David J Robbins   +13 more
doaj   +1 more source