Results 51 to 60 of about 402,657 (223)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Frontiers in Immunology, 2023
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the
Céline Cuche, Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Marie Juzans, Hélène Laude, Marie-Noëlle Ungeheuer, Daniel Krentzel, Maria Isabella Gariboldi, Daniel Scott-Algara, Marianne Madec, Sophie Goyard, Sophie Goyard, Camille Floch, Camille Floch, Gaëlle Chauveau-Le Friec, Pierre Lafaye, Charlotte Renaudat, Muriel Le Bidan, Christine Micallef, Sandrine Schmutz, Sébastien Mella, Sébastien Mella, Sophie Novault, Milena Hasan, Darragh Duffy, Vincenzo Di Bartolo, Andrés Alcover   +27 more
doaj   +1 more source

The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial

BMC Gastroenterology, 2022
Background Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal adenomas.
Jasmijn D. G. Linssen, Sanne M. van Neerven, Arthur S. Aelvoet, Clara C. Elbers, Louis Vermeulen, Evelien Dekker   +5 more
doaj   +1 more source

Poliposis linfomatosa intestinal Intestinal lymphomatous polyposis

Medisan, 2009
Se expone el caso clínico de un paciente de 55 años de edad, de piel blanca, que acudió a la consulta de Gastroenterología por presentar diarreas desde hacía alrededor de un año, dolor abdominal difuso, pérdida de peso, astenia y anorexia.
Cesar Falagán Andina, Elba Patricia Cabezas Niubó, Inocente Rodríguez Reyes, Lilibet Zamora Cabezas, Jesús Fernández Duharte   +4 more
doaj   +2 more sources

Small Bowel Tumors and Polyposis: How to Approach and Manage?

The Korean Journal of Gastroenterology, 2018
Although small bowel the mainly occupies the most part of the gastrointestinal tract, small intestine tumors are rare, insidious in clinical presentation, and frequently represent a diagnostic and management challenge.
Bong Min Ko
doaj   +1 more source

Intestinal polyposis syndromes

, 2018
Introduction: Intestinal polyposis syndromes are relatively rare genetic diseases characterised by the development of hundreds to thousands of adenomatous polyps along the large bowel. They can be divided, based on histology, into the broad categories of
Koynova, Ivanina; Medical University of Varna, Todorov, Pavel; Medical University of Varna, Draganova, Vyara; Second Surgery Department, St. Marina University Hospital; Medical University of Varna, Megdat, Sesil; Medical University of Varna, Atanasova, Elitsa; Medical University of Varna   +4 more
core   +1 more source

Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective

Journal of Developmental Biology, 2018
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC)
Ai Tian, Hassina Benchabane, Yashi Ahmed
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Paradoxically Augmented Anti-Tumorigenic Action of Proton Pump Inhibitor and Gastrin in APCMin/+ Intestinal Polyposis Model1

Neoplasia: An International Journal for Oncology Research, 2014
Though long-term administration of proton pump inhibitor (PPI) imposed the risk of gastrointestinal track tumorigenesis by accompanied hypergastrinemia, no overt increases of colon cancer risk were witnessed after a long-term cohort study.
Young-Min Han, Ki Baik Hahm, Jong-Min Park, Sung Pyo Hong, Eun-Hee Kim   +4 more
doaj   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source