Results 61 to 70 of about 32,367 (234)
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
PTEN-deficient intestinal stem cells initiate intestinal polyposis [PDF]
Nature Genetics, 2007 Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts, which contain intestinal stem cells (ISCs). In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement.
Xi C, He +14 more
openaire +2 more sources
Histopathology, EarlyView.Sessile serrated lesions with dysplasia represent a critical step in colorectal carcinogenesis. While routine histologic diagnosis is generally reliable and positive diagnostic trends are observed, subtle dysplastic changes may be overlooked. Targeted use of MLH1 immunohistochemistry provides meaningful diagnostic support in selected sessile serrated ...
Valentina Angerilli +9 more
wiley +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.CADe assistance did not significantly change the gaze‐shift distance overall, but it reduced gaze‐shift distance among CADe‐experienced endoscopists. CADe may be associated with reduced eye strain, depending on the endoscopist's CADe experience. ABSTRACT Background and Aim Computer‐aided detection (CADe) facilitates colorectal lesion detection, but it ...
Shun Ito +6 more
wiley +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins +5 more
wiley +1 more source
Identification of human papillomavirus DNA in cutaneous lesions of Cowden syndrome [PDF]
, 2003 Background: Cowden syndrome (CS) or multiple hamartoma syndrome is a cancer-associated genodermatosis inherited in an autosomal dominant pattern. One of the diagnostic criteria is facial papules which are felt to be trichilemmomas, benign hair follicle ...
Burgdorf, Walter H. C. +4 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 2, June 2026.This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
Polyposis of gastrointestinal tract after COVID-19 mRNA vaccination: a report of two cases [PDF]
Clinical EndoscopyCronkhite-Canada syndrome is a rare gastrointestinal polyposis syndrome with distinctive clinical features and endoscopic findings. Diagnosis can be challenging without suspicion, and the disease carries high mortality due to complications such as ...
Jun Ho Kim, Eun Hye Oh, Dong Soo Han
doaj +1 more source