Results 81 to 90 of about 402,657 (223)
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation
Respirology, EarlyView.ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley +1 more source
Reexamining Multisystem Desmoid Tumors Linked to Gardner’s Syndrome: A Clinical Case
Case Reports in Gastrointestinal MedicineA variation of familial adenomatous polyposis (FAP), known as Gardner’s syndrome (GS), can manifest as extraintestinal tumors, such as desmoid tumors (DTs). A key part in the diagnosing process is played by the clinician.
Haijia Zhang +3 more
doaj +1 more source
Computed tomography findings of diffuse gastrointestinal mantle cell lymphoma
Radiology Case Reports, 2017 Multiple lymphomatous polyposis is an uncommon type of primary non-Hodgkin's lymphoma, characterized by multiple lymphomatous polyps along the gastrointestinal tract.
Fernando Ide Yamauchi, MD +4 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy +2 more
wiley +1 more source
Epiphora: A Structured Diagnostic Approach for the Otolaryngologist
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Introduction Epiphora, or excessive tearing, has historically been predominantly managed by ophthalmologists. However, as there is substantial overlap between ophthalmic and otolaryngologic anatomy and pathology that may contribute to epiphora, patients with this symptom often present to otolaryngologists as well.
Luke M. O'Neil +7 more
wiley +1 more source
The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented between ear, nose, and throat (ENT), allergy, and pulmonology.
Diego M. Conti +16 more
wiley +1 more source
Pre‐Seasonal Treatment With Recombinant Carrier‐Based Birch Vaccine Improves Birch Pollen Allergy
Allergy, EarlyView.We conducted a two stage SCIT trial with GNR‐127 containing a recombinant fusion protein consisting of Bet v 1 and Mal d 1‐derived peptides fused to PreS from HBV. Stage 1 identified two safe maximum tolerated doses (40 μg and 80 μg). In the following Stage 2, five preseasonal injections were well tolerated, induced dose‐dependent allergen‐specific IgG,
Musa R. Khaitov +43 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review
Clinical Genetics, EarlyView.There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson +6 more
wiley +1 more source