Results 51 to 60 of about 244,058 (306)
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
Intestinal Stem Cells Exhibit Conditional Circadian Clock Function
Stem Cell Reports, 2018 Summary: The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions.
Kathyani Parasram +6 more
doaj +1 more source
Stem Cell Reports, 2020 Summary: Robust production of terminally differentiated cells from self-renewing resident stem cells is essential to maintain proper tissue architecture and physiological functions, especially in high-turnover tissues.
Fanju W. Meng +2 more
doaj +1 more source
Cell & Bioscience, 2021 Background Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of their development remain poorly ...
Lu Xue +5 more
doaj +1 more source
Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells
Cell Reports, 2020 Summary: Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequent ...
Mónica Romera-Hernández +7 more
doaj +1 more source
Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]
, 2018 Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey +2 more
core +2 more sources
Regulation of Intestinal Stem Cells [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2004 Stem cells are essential for maintaining the tissue integrity of all adult tissues. The manipulation of adult stem cells has the potential for cell regeneration and in curing diseases; however, the intestinal stem cell remains enigmatic. Although much work has focused on characterization of the intestinal stem cell within its in vivo niche, the lack of
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source