Results 71 to 80 of about 128,505 (309)

Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure

Toxins, 2020
The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route of exposure remain less known. We explored the toxic effects of DON on intestinal barrier functions and stem cells after DON microinjection (luminal exposure)
Hikaru Hanyu, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Keisuke Tanaka, Kinuko Uno, Katsuhiro Miyajima, Yuki Saito, Ken Iwatsuki, Makoto Shimizu, Miki Tadaishi, Kazuo Kobayashi-Hattori   +11 more
doaj   +1 more source

Ischemic preconditioning increased the intestinal stem cell activities in the intestinal crypts in mice

, 2017
Background: Ischemic preconditioning (IPC) can protect against ischemia-reperfusion injury in the small intestine. Because intestinal stem cells (ISCs) control the recovery and growth of intestinal villi, this study investigated whether IPC had any ...
Chen, Yun;Lee, Shih-Hua;Tsai, Ya-Hui;Tseng, Sheng-Hong, 曾勝弘   +1 more
core   +1 more source

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation [PDF]

, 2016
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling ...
Wakeham, A., Mana, Miyeko D, Sato, T., Pollett, Aaron, Dominguez-Brauer, Carmen, Tworzyanski, Leanne, Pollett, A., Sabatini, David M., Yilmaz, Omer H., Sheng, Yi, Elia, A. J., Reardon, Colin, Inoue, Satoshi, Cox, Maureen A., Yilmaz, Omer H, Cairns, Robert, Wakeham, Andrew, Haight, J., Fortin, Jérôme M, van Es, Johan H, Cairns, R., Reardon, C., van Es, J. H., Mak, Tak W, Nechanitzky, Robert, Sabatini, D. M., Elia, Andrew J., Brauer, Patrick M, Elia, Andrew J, Hao, Zhenyue, Nechanitzky, R., Clevers, Hans, Brauer, Patrick M., Inoue, S., Yilmaz, O. H., Marques, Ana, Fortin, Jérôme M., Dominguez-Brauer, C., Brauer, P. M., Silvester, Jennifer, Mak, T. W., van Es, Johan H., Fortin, J. M., Sabatini, David M, Mak, Tak W., Cox, Maureen A, Marques, A., Sato, Toshiro, Mana, M. D., Cox, M. A., Sheng, Y., Silvester, J., Tworzyanski, L., Haight, Jillian, Clevers, H., Chio, II, Mana, Miyeko D., Hao, Z., Chio, Iok In Christine   +58 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]

, 2014
Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A., Reichert, Heinrich, Burkard, Thomas R., Homem, Catarina C.F., Saini, Nidhi, Eroglu, Elif, Homem, Catarina C. F., Jiang, Yanrui   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

Cell Reports, 2017
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model, we
Han Na Suh, Moon Jong Kim, Youn-Sang Jung, Esther M. Lien, Sohee Jun, Jae-Il Park   +5 more
doaj   +1 more source

The origin of intestinal stem cells in Drosophila [PDF]

Developmental Dynamics, 2011
AbstractRenewing tissues in the adult organism such as the gastrointestinal (GI) epithelium depend on stem cells for epithelial maintenance and repair. Yet, little is known about the developmental origins of adult stem cells and their niches. Studies of Drosophila adult midgut precursors (AMPs), a population of endodermal progenitors, demonstrate that ...
openaire   +2 more sources

Isolation and characterisation of mouse amniotic fluid stem cells: study of their origin, regenerative potential and reprogramming into pluripotent cells [PDF]

, 2013
Introduction: Stem cells are defined by their ability to proliferate for a long period of time, a property known as ‘self-renewal’, and to give rise to differentiated cells.
Bertin, Enrica
core  

Update on small intestinal stem cells

, 2013
Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self ...
Lattanzi, Wanda, Gasbarrini, Antonio, Puglisi, Maria Ausiliatrice, Tesori, Valentina   +3 more
core   +1 more source