Results 81 to 90 of about 128,505 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. [PDF]

PLoS ONE, 2013
Lgr5 was identified as a promising gastrointestinal tract stem cell marker in mice. Lineage tracing indicates that Lgr5(+) cells may not only be the cells responsible for the origin of tumors; they may also be the so-called cancer stem cells.
Bo Gun Jang, Byung Lan Lee, Woo Ho Kim
doaj   +1 more source

Recent Advances in Intestinal Stem Cells [PDF]

Current Molecular Biology Reports, 2017
The intestine is a dynamic organ with rapid stem cell division generating epithelial cells that mature and apoptose in 3-5 days. Rapid turnover maintains the epithelial barrier and homeostasis. Current insights on intestinal stem cells (ISCs) and their regulation are discussed here.The Lgr5+ ISCs maintain intestinal homeostasis by dividing ...
Laura R, McCabe, Narayanan, Parameswaran
openaire   +2 more sources

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

, 2016
Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell types at near-normal ratios.
Seno, Hiroshi, Clevers, Hans, Wiebrands, Kay, van Oudenaarden, Alexander, Basak, Onur, Beumer, Joep   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells

Stem Cell Research, 2015
K-Ras is a monomeric GTPase that controls cellular and tissue homeostasis. Prior studies demonstrated that mutationally activated K-Ras (K-RasG12D) signals through MEK to promote expansion and hyperproliferation of the highly mitotically active transit ...
Jessica J. Gierut, Jesse Lyons, Manasvi S. Shah, Casie Genetti, David T. Breault, Kevin M. Haigis   +5 more
doaj   +1 more source

The nature of intestinal stem cells' nurture [PDF]

EMBO reports, 2011
Mustata et al demonstrate in this issue of EMBO reports that Lgr4 expression in the stem cells and transit amplifying cells of the intestinal crypts is required for the establishment of the stem cell niche and also for the maintenance of intestinal stem
Roth, S, Fodde, Riccardo
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation

Cell Regeneration
Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions. A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process.
Yehua Li, Mengxian Zhang, Xianrun Ma, Ye-Guang Chen   +3 more
doaj   +1 more source

NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken [PDF]

, 2001
Non-mammalian NK cells have not been characterized in detail; however, their analysis is essential for the understanding of the NK cell receptor phylogeny.
Manfred Stangassinger, Göbel, Thomas W. F., Stangassinger, Manfred, Kaspers, Bernd, Thomas W. F. Göbel, Bernd Kaspers   +5 more
core   +1 more source