Results 61 to 70 of about 244,058 (306)

E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]

, 2015
Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke, Alastair Watson, Andrew D Campbell, Ann Hedley, Aoife Maguire, Brendan Doyle, David J Huels, Fatih Ceteci, Fei Song, Gabriela Kalna, Guenievre Moreaux, James Matthews, Karen R Reed, Lee Parry, Lionel Larue, Marc Leushacke, Nick Barker, Ola Söderberg, Owen J Sansom, Rachel A Ridgway, Runjan Chetty, Serra S, Simon Leedham, Sorina Radulescu, Sparks AB, Stefano Serra, Sujata Biswas, Valerie S Meniel   +27 more
core   +2 more sources

Small intestinal stem cell markers

Journal of Anatomy, 2008
AbstractStem cells hold great promise for regenerative medicine but remain elusive in many tissues, including the small intestine, where it is well accepted that the epithelium is maintained by intestinal stem cells located in the crypts. The lack of established markers to prospectively identify intestinal stem cells has necessitated the use of ...
Robert K, Montgomery, David T, Breault
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

MRISCs protect colonic stem cells from inflammatory damage

Cell Regeneration, 2021
Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals.
Guoli Zhu, Rongwen Xi
doaj   +1 more source

From birth to death: The hardworking life of Paneth cell in the small intestine

Frontiers in Immunology, 2023
Paneth cells are a group of unique intestinal epithelial cells, and they play an important role in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of ...
Chenbin Cui, Fangke Wang, Yao Zheng, Hongkui Wei, Jian Peng, Jian Peng   +5 more
doaj   +1 more source

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. [PDF]

, 2018
Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells1. Whereas dynamics of epithelial stem cells during homeostasis are increasingly well understood, how stem cells are redirected from a tissue ...
de Sauvage, Frederic J, Klein, Ophir D, Landman, Tyler A, Locksley, Richard M, Marangoni, Pauline, Nusse, Ysbrand M, Rosendahl-Huber, Axel KM, Savage, Adam K   +7 more
core  

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. [PDF]

, 2015
The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised
Abdou, Al-Anzi, Antonello, Athippozhy, Avila, Bajgar, Barnes, Biteau, Biteau, Bontonou, Buchon, Busson, Carey, Carvalho, Casirola, Cerf, Charles, Choi, Cognigni, David, Economos, Fahrbach, Flatt, Flatt, Flatt, Glinoer, Gore, Gwinn, Hammond, Hansen, Hildebrandt, Horton, Jiang, Jindra, Jindra, Jowett, Keller, Klepsatel, Koren, Koyama, Kubli, Kunte, Langevin, Lee, Lemaitre, Li, Lodhi, Marianes, Marois, McGuire, Micchelli, Middleton, Min, Mirth, Mirth, Moshitzky, Navare, Nijhout, O'Brien, Padmanabha, Palm, Parker, Parra-Peralbo, Phillips, Piersma, R Development Core Team, Rauschenbach, Rera, Riddiford, Roa, Rogina, Ryu, Sarraf-Zadeh, Schneider, Seegmiller, Shimano, Shin, Sieber, Siegmund, Song, Speakman, Theopold, Tiu, Ueyama, Venables, Wen, Wigby, Wyatt, Yamamoto, Yin, Zhang   +90 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

Stem Cell Reports, 2015
The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts.
Dustin J. Flanagan, Toby J. Phesse, Nick Barker, Renate H.M. Schwab, Nancy Amin, Jordane Malaterre, Daniel E. Stange, Cameron J. Nowell, Scott A. Currie, Jarel T.S. Saw, Eva Beuchert, Robert G. Ramsay, Owen J. Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan   +15 more
doaj   +1 more source

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]

, 2013
Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D, Falk, Gary W, Hartman, Kira G, Lynch, John P, Martín, Martín G, Rustgi, Anil K, Yu, Jian   +6 more
core   +2 more sources