Results 41 to 50 of about 1,734,969 (325)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Long-term Outcome After Nonvascularized Rectus Fascia Transplantation in Solid Organ Transplantation: A Global Multicenter IIRTA Survey

Transplantation Direct
Background. Abdominal wall (AW) closure after solid organ transplantation (SOT) is challenging in case of loss of abdominal domain and/or large-for-size grafts. Primary closure is crucial to avoid open abdomen-associated morbidity and mortality.
Nele Van De Winkel, MD, Ewout Muylle, BSc, Emilio Canovai, MD, PhD, Irum Amin, MD, Andrew Butler, MD, PhD, Rodrigo Vianna, MD, Gennaro Selvaggi, MD, Pablo Farinelli, MD, Gabriel Gondolesi, MD, Carmelo Loinaz, MD, PhD, Iago Justo, MD, PhD, Hector Vilca-Melendez, MD, Ulrika Skogsberg Dahlgren, MD, Gustaf Herlenius, MD, PhD, Alireza Shamsaeefar, MD, Hamed Nikoupour, MD, Antoine Dubois, MD, Marc Miserez, MD, PhD, André D’Hoore, MD, PhD, Robert Venick, MD, Jacques Pirenne, MD, PhD, Laurens J. Ceulemans, MD, PhD   +21 more
doaj   +1 more source

Bridging Liver Transplantation in the Treatment of Intestinal Failure Associated Liver Disease in Infants—A Bridge Too Far?

Children, 2022
Infants with intestinal failure associated liver disease (IFALD) requiring liver and bowel transplant have a high mortality on the transplant waiting list due to the scarcity of the size-matched donor organs.
Abubakar Sharif, Khalid Sharif, Darius F. Mirza, Girish L. Gupte   +3 more
doaj   +1 more source

Developing Trends in the Intestinal Transplant Waitlist

American Journal of Transplantation, 2014
The United Network for Organ Sharing database was examined for trends in the intestinal transplant (ITx) waitlist from 1993 to 2012, dividing into listings for isolated ITx versus liver‐intestine transplant (L‐ITx).
K. Khan, C. Desai, M. Mete, S. Desale, R. Girlanda, J. Hawksworth, C. Matsumoto, Stuart S Kaufman, Thomas M. Fishbein   +8 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Massive bowel resection for children with non-short bowel syndrome intestinal failure

Intestinal Failure
Introduction: Pediatric patients with chronic intestinal pseudo-obstruction (CIPO) and congenital diarrheas and enteropathies (CODE) are unique intestinal failure (IF) patient populations.
FY Takamatsu, P. Wales, C. Belza, E. Garofalo, S. Wong-Sterling, D. Yanchis, G. Courtney-Martin, Y. Avitzur   +7 more
doaj   +1 more source

Intestinal transplantation in children under FK 506 immunosuppression [PDF]

, 1993
Intestinal transplantation, solitary (n = 3) or in combination with the liver (n = 7), was performed in 10 pediatric patients with intestinal failure. The liver was only replaced if there was liver failure and portal hypertension.
Adrian Casavilla, Andreas G. Tzakis, Anthony J. Demetris, Bakr Nour, David H. Van Thiel, Eduardo Yunis, Goulet, Grant, Iwaki, Jorge Reyes, Kareem Abu-Elmagd, Murase, Murase, Rick Selby, Samuel Kocoshis, Satoru Todo, Schraut, Shaffer, Starzl, Starzl, Starzl, Thomas E. Starzl, Todo, Todo, Tzakis, Tzakis, Zhong   +26 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Live transplantation in children with biliary atresia and vascular anomalies [PDF]

, 1974
Eight of 29 infants and children undergoing orthotopic liver transplantation for extrahepatic biliary atresia had associated major vascular anomalies.
Lilly, JR, Starzl, TE
core   +1 more source