Results 11 to 20 of about 1,163,172 (245)

Organization of the human intestine at single-cell resolution

Nature, 2023
Intestinal cell types are organized into distinct neighbourhoods and communities within the healthy human intestine, with distinct immunological niches. The intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune ...
J. Hickey, Winston R. Becker, Stephanie A. Nevins, Aaron M. Horning, Almudena Espín Pérez, Chenchen Zhu, Bokai Zhu, Bei Wei, R. Chiu, Derek C. Chen, Daniel L. Cotter, Edward D Esplin, Annika K. Weimer, Chiara Caraccio, V. Venkataraaman, C. Schürch, Sarah Black, Maria Brbić, Kaidi Cao, Shuxiao Chen, Weiruo Zhang, Emma Monte, Nancy R. Zhang, Zongming Ma, J. Leskovec, Zhengyan Zhang, Shin‐Yi Lin, T. Longacre, S. Plevritis, Yiing Lin, Garry P. Nolan, W.J. Greenleaf, Michael P. Snyder   +32 more
semanticscholar   +1 more source

The Role of the Intestine in the Development of Hyperuricemia

Frontiers in Immunology, 2022
Gout is a common inflammatory arthritis caused by the deposition of sodium urate crystals in the joints. Hyperuricemia is the fundamental factor of gout.
Hui-ming Yin, Na Liu, Jie Chen
semanticscholar   +1 more source

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.

Annual Review of Immunology, 2020
The gastrointestinal tract harbors numerous commensal bacteria, referred to as the microbiota, that benefit host health by digesting dietary components and eliminating pathogens. The intestinal microbiota maintains epithelial barrier integrity and shapes
H. Kayama, Ryu Okumura, K. Takeda
semanticscholar   +1 more source

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Journal of Biological Chemistry, 2020
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also harbors a large and diverse microbial population collectively called the gut microbiome (microbiota).
Rashi Singhal, Y. Shah
semanticscholar   +1 more source

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]

, 2019
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R., Ismagilov, Rustem F., Rolando, Justin C.   +2 more
core   +1 more source

Regulation of bicarbonate secretion in marine fish intestine by the calcium-sensing receptor [PDF]

, 2018
In marine fish, high epithelial intestinal HCO3- secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis.
Fuentes, Juan, Gregorio, Silvia
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Effect of ischemia on the canine large bowel: A comparison with the small intestine [PDF]

, 1996
Mucosal injury caused by ischemia and reperfusion has been well documented with the small intestine, but little is known about the colon. In the present study, the effect of warm and cold ischemia on the canine colon was studied and compared to that on ...
Ikoma, A, Nakamura, K, Starzl, TE, Takeyoshi, I, Todo, S, Zhang, S, Zhu, Y   +6 more
core   +1 more source

To respond or not to respond - a personal perspective of intestinal tolerance [PDF]

, 2018
For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka, A Goubier, A Iwasaki, A Konrad, A Limmer, A Mortha, A Vaillant, AJ MacPherson, Allan McI. Mowat, AM Mowat, B Cassani, B Dubois, B Jabri, B Johansson-Lindbom, C Asseman, C Berlin, C Siewert, C Varol, CC Bain, CC Bain, CL Scott, CL Scott, CM Sun, CR Mackay, CR Stokes, D Esterhazy, D Fina, D Mucida, D Sichien, DP McGovern, DS Shouval, E Jaensson, E Jaensson-Gyllenback, E Mazzini, E Zigmond, EJ Kunkel, EM Nilsen, EM Nilsen, F Broere, F Ginhoux, F Hauet-Broere, F Powrie, FG Chirdo, G Lack, G Matteoli, G Mayrhofer, G Monteleone, GG MacPherson, H Arentz-Hanson, H Fukaura, H Tlaskalova, HG Wells, HL Klaasen, HL Weiner, HL Weiner, I Vicente-Suarez, ID Iliev, II Ivanov, J Farache, J Farache, JA Mattingly, JA Mattingly, JB Sun, JF Heremans, JH Niess, JL Coombes, JL Gowans, JL Viney, JM Blander, JP Hugot, JR Battisto, JR McDole, K Atarashi, K Atarashi, K Lahl, K Nagatani, K Takeda, KG McDonald, KM Luda, KM Smith, KP Zimmer, KS Kim, L Maiuri, L Maiuri, L Saurer, LA Hanson, LA Reynolds, LA Waaij van der, LM Sollid, M Boucard-Jourdin, M Butler, M Chieppa, M Karlsson, M Murai, M Rescigno, M Rimoldi, M Tsuji, M Yoshida, MH Jang, MH Jang, MO Li, MR Hepworth, MR Karlsson, MW Chase, N Korneychuk, N Satoh-Takayama, N Sudo, O Schulz, P Brandtzaeg, P Morrissey, PA Crabbe, PB Carter, PM Smith, R Bouziat, R Kuhn, R Zeng, R Zeng, RE Araya, RL Owen, RW DePaolo, S Hue, S Husby, S Husby, S Kawamoto, S Strobel, S Strobel, S Veenbergen, S Wilks, SI Hammerschmidt, SK Mazmanian, SV Kim, T Joeris, T Worbs, TB Tomasi Jr, TL Denning, U Hadis, V Cerovic, V Gaboriau-Routhiau, Y Chen, Y Cong, Y Ogura, ZM Falchuk, Ø Molberg   +142 more
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A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Nature Biomedical Engineering, 2019
The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living human intestinal cells and their
Sasan Jalili-Firoozinezhad, F. Gazzaniga, E. Calamari, Diogo M. Camacho, Cicely Fadel, Amir Bein, Ben Swenor, Bret A. Nestor, Michael J. Cronce, Alessio Tovaglieri, O. Levy, K. Gregory, D. Breault, J. Cabral, Dennis L. Kasper, R. Novák, D. Ingber   +16 more
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Viable bacterial colonization is highly limited in the human intestine in utero

Nature Medicine, 2020
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet whether viable microbes exist in utero and interact with the intestinal immune system is unknown.
E. Rackaityte, J. Halkias, E. Fukui, V. Mendoza, C. Hayzelden, E. Crawford, K. Fujimura, T. Burt, S. Lynch   +8 more
semanticscholar   +1 more source