Results 231 to 240 of about 791,437 (254)

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

The endoplasmic reticulum plays a key role in α-cell intracellular Ca²⁺ dynamics and glucose-regulated glucagon secretion in mouse islets. [PDF]

iScience
Acreman S, Ma J, Denwood G, Gao R, Tarasov A, Rorsman P, Zhang Q.   +6 more
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

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Metabolomics in cancer research and emerging applications in clinical oncology

Ca-A Cancer Journal for Clinicians, 2021
David Kirsch, Matthew G Vander Heiden, Jason Locasale   +2 more
exaly  

Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

Cell, 2022
Yi Chen, Shang Cai, Aikun Fu
exaly  

A Comprehensive Review on Intracellular Delivery

Advanced Materials, 2021
Dorsa Morshedi Rad, Maryam Alsadat Rad, Majid Ebrahimi Warkiani   +2 more
exaly  

Carbon-Dot-Based Probe Designed to Detect Intracellular pH in Fungal Cells for Building Its Relationship with Intracellular Polysaccharide

ACS Sustainable Chemistry and Engineering, 2021
Xiaobo Sun, Jinping Wang
exaly  

Dynamic Polymer Amphiphiles for Efficient Intracellular and In Vivo Protein Delivery

Advanced Materials, 2021
Yiyun Cheng, Yiwen Li, Qianqian Fan
exaly  

Eradicating intracellular MRSA targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

Journal of Controlled Release, 2021
Gongming Shi, Beibei Xie, Yun He
exaly