Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion [PDF]
, 2004 In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs).
Treves, Susan +12 more
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Journal of Pharmacological Sciences, 2013 Calcium is a ubiquitous intracellular signaling molecule required for initiating and regulating neuronal functions. Ca2+ release from intracellular stores in the endoplasmic reticulum into intracellular spaces via intracellular Ca2+–releasing channels ...
Koji Mizuno +2 more
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PLoS ONE, 2010 Disturbances in intracellular calcium homeostasis are likely prominent and causative factors leading to neuronal cell death in Alzheimer's disease (AD). Familial AD (FAD) is early-onset and exhibits autosomal dominant inheritance.
Emily Stieren +4 more
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Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. [PDF]
PLoS ONE, 2009 Much of our current understanding about neurodegenerative diseases can be attributed to the study of inherited forms of these disorders. For example, mutations in the presenilin 1 and 2 genes have been linked to early onset familial forms of Alzheimer's ...
Kinga Michno +4 more
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Neuronal calcium sparks and intracellular calcium “noise” [PDF]
Proceedings of the National Academy of Sciences, 1999 Intracellular calcium ions are involved in many forms of cellular function. To accommodate so many control functions, a complex spatiotemporal organization of calcium signaling has developed. In both excitable and nonexcitable cells, calcium signaling was found to fluctuate.
N, Melamed-Book +3 more
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Calcium Dynamics Regulate Protective Responses and Growth of Staphylococcus aureus in Macrophages
Biomolecular Concepts, 2020 Staphylococcus aureus (S. aureus) is a gram-positive bacteria, which causes various fatal respiratory infections including pneumonia. The emergence of Methicillin-Resistance Staphylococcus aureus (MRSA) demands a thorough understanding of host-pathogen ...
Verma Chaitenya +7 more
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Local calcium elevation and cell elongation initiate guided motility in electrically stimulated osteoblast-like cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Investigation of the mechanisms of guided cell migration can contribute to our understanding of many crucial biological processes, such as development and regeneration.
Nurdan Ozkucur +4 more
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The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
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Journal of Tropical Life Science, 2017 Cervical cancer is the third most commonly diagnosed cancer and fourth leading cause of women death with 8% of total death caused by cancer in women in 2008.
Natanael Untario +3 more
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Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]
, 1990 In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S. +3 more
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